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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
radical generation
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "radical generation" in MCE Product Catalog:
7
3
Category:
Vitaceae Extract Microorganisms Vitis vinifera cv. Zalema Plants Disease Research Fields Inflammation/Immunology Saccharides Monosaccharides
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3 Cited Publications
Synonyms: 2,2'-Azodiisobutyramidine dihydrochloride
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AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis . AAPH decomposes at 37°C to generate an alkyl radical, is used as an initiator. In the presence of oxygen, these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity, which could ultimately lead to hemolysis .
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2 Cited Publications
Cat. No.: HY-W013508
CAS No.: 106797-53-9
1
1 Cited Publications
Cat. No.: HY-W050000
CAS No.: 101328-85-2
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OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation .
Cat. No.: HY-W115721
CAS No.: 523-21-7
Synonyms: Sodium rhodizonate dibasic
Cat. No.: HY-163074
CAS No.: 1517780-59-4
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Ferroptosis-IN-6 is a potent Ferroptosis inhibitor with an EC50 of 25.5 nM. Ferroptosis-IN-6 acts as a radical-trapping antioxidant, relying on the synergistic effect of ortho-hydroxyamine to specifically block lethal lipid ROS accumulation without affecting iron homeostasis and ROS generation pathways. Ferroptosis-IN-6 can be used for research on renal ischemia-reperfusion injury .
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Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
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Coenzyme Q2 is a benzoquinone electron carrier in the mitochondrial electron transport chain and a p53-dependent apoptosis inducer. Coenzyme Q2 induces p53 phosphorylation at Ser15, promoting p53 accumulation and functional activation. Coenzyme Q2 induces ROS generation, caspase-3 activation, DNA fragmentation, phosphatidylserine externalization, mitochondrial permeability transition pore opening, and oxidative phosphorylation uncoupling. Coenzyme Q2 inhibits Complex I, Complex III, and Complex IV activities, disrupting electron transport and membrane potential generation. Coenzyme Q2 induces excessive mitochondrial proton leak in forebrain mitochondria. Coenzyme Q2 causes loss of righting reflex in mice, accompanied by slow-wave delta EEG activity and reversible loss of wakefulness. Coenzyme Q2 inhibits lipid peroxidation and scavenges superoxide radicals. Coenzyme Q2 is used in research on leukemia, myocardial ischemia-reperfusion injury, and mitochondrial encephalomyopathy .
Cat. No.: HY-W145481A
CAS No.: 11078-30-1
Synonyms: Carob galactomannan
Cat. No.: HY-129242S
CAS No.: 80404-14-4
Synonyms: 4-Oxo-Tempo-15N,d16
Tempone- 15N,d16 (4-Oxo-Tempo 15N,D16) is the deuterated, 15N-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-N3596
CAS No.: 84575-10-0
Synonyms: Aquillochin
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Vitaceae Extract Microorganisms Vitis vinifera cv. Zalema Plants Saccharides Monosaccharides
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Cat. No.: HY-42682S1
CAS No.: 478518-54-6
Synonyms: D-Galactosamine-13C hydrochloride
Cat. No.: HY-U00005
CAS No.: 145600-69-7
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AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
Cat. No.: HY-N8447
CAS No.: 1891097-17-8
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Cat. No.: HY-119092
CAS No.: 89194-77-4
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Bisaramil is an orally active antiarrhythmic agent. Bisaramil exerts concentration dependent inhibitory effect on PMA-stimulated free radical generation and prolonged the time lag concentration dependently .
Cat. No.: HY-18716
CAS No.: 1124347-33-6
Dextrorotation nimorazole phosphate ester is a fourth-generation nitroimidazole phosphate prodrug that generates DNA-damaging free radicals through anaerobic-specific nitro reduction. Dextrorotation nimorazole phosphate ester can be used to research anaerobic bacterial and protozoan infections .
Cat. No.: HY-W686216
CAS No.: 312611-92-0
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VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease .
Cat. No.: HY-116778
CAS No.: 51982-36-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
