Prostaglandin G2 

Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A₂ production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury^[1][2].

Prostaglandin G2 (0.6-1 μg) incubated with Indomethacin (HY-14397)-pretreated washed human platelets generates an unstable rabbit aorta contracting factor (thromboxane A₂) with a half-life of 34 sec at 37 °C that induces strong contraction of isolated rabbit aorta strips^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prostaglandin G2 (10 μg/mL; local administration under cranial window; single exposure for 15 min) induces cerebral arteriole injury in anesthetized cats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

368.46

C₂₀H₃₂O₆

51982-36-6

Liquid

Colorless to light yellow

CCCCC[C@H](OO)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Hamberg M, et al. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci U S A. 1975;72(8):2994-2998.  [Content Brief]

  [2]. Kontos H A, et al. Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science, 1980, 209(4462): 1242-1245.