Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
reductive metabolite
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "reductive metabolite" in MCE Product Catalog:
9
9 Publications Verification
Target:
Research Areas:
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
9
9 Publications Verification
Target:
Research Areas:
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
6
2
Category:
Disease Research Antibacterial Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology
Target:
1
Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .
Cat. No.: HY-30004
CAS No.: 22059-21-8
Cat. No.: HY-177475
CAS No.: 60701-99-7
Synonyms: 1-Arachidonoyl-sn-glycero-3-phosphocholine
Target:
Research Areas:
LysoPC 20:4 (20:4) (1-Arachidonoyl-sn-glycero-3-phosphocholine) is a serum metabolite. LysoPC 20:4 (20:4) decreases in tumor-bearing mice, but the reduction is not significant. LysoPC (20:4) can be used in cancer and obesity-related research .
Target:
Cat. No.: HY-W353102
CAS No.: 1806-98-0
Category:
Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology Steroids
Target:
Cat. No.: HY-W016099
CAS No.: 74003-63-7
Synonyms: MQCA
Target:
Research Areas:
3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle .
Cat. No.: HY-117580
CAS No.: 13951-70-7
Synonyms: OH-PRED
Target:
Research Areas:
16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .
Cat. No.: HY-30004R
CAS No.: 22059-21-8
Cat. No.: HY-W016099S
CAS No.: 2244217-93-2
Synonyms: MQCA-d4
Research Areas:
12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR-mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation .
Cat. No.: HY-W129615
CAS No.: 527-20-8
Synonyms: 2,3,4,5,6-Pentachloroaniline
Target:
Research Areas:
Pentachloroaniline (2,3,4,5,6-Pentachloroaniline) is a pentachlorinated aromatic amine pesticide that serves as a substrate for reductive dehalogenation reactions and a metabolite of quintozene. Pentachloroaniline can be converted into different trichloroanilines and dichloroanilines via reduction. Pentachloroaniline cannot induce its own dehalogenation activity in Desulfitobacterium frappieri PCP-1, and its conversion process must rely on induction by 3,5-dichlorophenol .
Cat. No.: HY-125916
CAS No.: 58523-30-1
Target:
Target:
Cat. No.: HY-113224R
CAS No.: 313-04-2
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
