15087-02-2
Chemical Structure
Estradiol 17-(β-D-Glucuronide) sodium
- CAS No.: 15087-02-2
- Formula:C24H31NaO8
- Molecular Weight:470.49
IUPAC Name: sodium (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(((8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)oxy)tetrahydro-2H-pyran-2-carboxylate
InChIKey: UQSHTUQZFYMYFO-VGYGJRAWSA-M
SMILES: C[C@@]12[C@](CC[C@@H]2O[C@]3([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O[Na])=O)([H])[C@@]4([H])[C@](C5=C(C=C(O)C=C5)CC4)([H])CC1
Biological Activity: Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis[1][2].
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Estradiol 17-(β-D-Glucuronide) sodium | 98.91% | Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis. | ||||||||||||||||||||
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References
- [1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952. [Content Brief]
- [2]. Chen ZS, et al. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005;67(2):545-557. [Content Brief]
