70132-51-3
70132-51-3
Chemical Structure
Pimonidazole hydrochloride
- CAS No.: 70132-51-3
- Formula:C11H19ClN4O3
- Molecular Weight:290.75
IUPAC Name: 1-(2-nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol hydrochloride
InChIKey: SKUVJFHTKRTQQZ-UHFFFAOYSA-N
SMILES: OC(CN1C=CN=C1[N+]([O-])=O)CN2CCCCC2.Cl
Biological Activity: Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].
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Pimonidazole hydrochloride | 99.98% | Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia . | ||||||||||||||||||||
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Pimonidazole hydrochloride (Standard) | ≥98% | Pimonidazole (hydrochloride) (Standard) is the analytical standard of Pimonidazole (hydrochloride). This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia . | ||||||||||||||||||||
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References
- [1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7. [Content Brief]
- [2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639. [Content Brief]
