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  4. Ro 07-1902

Ro 07-1902 is a potent antitumor synergist. Ro 07-1902 enhances the antitumor effects of CCNU (HY-13669), Chlorambucil (HY-13593) and Cyclophosphamide (HY-17420). Ro 07-1902 exhibits no single-agent cytotoxicity and does not delay tumor growth. Ro 07-1902 can be used in research related to various cancers.

For research use only. We do not sell to patients.

Ro 07-1902

Ro 07-1902 Chemical Structure

CAS No. : 68160-71-4

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Ro 07-1902 Related Antibodies

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Description

Ro 07-1902 is a potent antitumor synergist. Ro 07-1902 enhances the antitumor effects of CCNU (HY-13669), Chlorambucil (HY-13593) and Cyclophosphamide (HY-17420). Ro 07-1902 exhibits no single-agent cytotoxicity and does not delay tumor growth. Ro 07-1902 can be used in research related to various cancers[1][2][3].

In Vitro

Ro 07-1902 has an octanol/water partition coefficient of 2.5 at pH 7.4, a value associated with potent enhancement of CCNU's anti-tumour effect in the KHT fibrosarcoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 07-1902 Related Antibodies
In Vivo

Ro 07-1902 (0.1-4.0 mmol/kg; i.p.; single administration) significantly potentiates the antitumor effect of CCNU against KHT fibrosarcoma in C3H/He mice[1].
Ro 07-1902 (1.0-2.0 μmol/g; i.p.; single administration) acts as a potent enhancer of cyclophosphamide cytotoxicity in C57Bl/Cbi mice bearing Lewis lung carcinoma[2].
Ro 07-1902 (1 mmol/kg; i.p.; single administration) enhances the tumor growth delay effect of chlorambucil on RIF-1 mouse sarcoma[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/He (both sexes, 12-16 weeks old, 20-30 g, KHT fibrosarcoma grown intramuscularly in hind limb)[1]
Dosage: 0.1 mmol/kg; 0.9 mmol/kg; 2.5 mmol/kg; 3.0 mmol/kg; 4.0 mmol/kg
Administration: i.p.; single dose 30 min before CCNU
Result: Exhibited Activity Index values of 3.1, 2.4, 4.1, and 3.3 at 2.5 mmol/kg, being 2.4-4.1 times more active than MISO at enhancing CCNU's anti-tumour effect.
Increased tumour growth delay for 10 mg/kg CCNU to exceed the growth delay caused by 20 mg/kg CCNU alone at 2.5 mmol/kg, resulting in a dose-modifying factor greater than 2.
Was considerably more active than MISO at low doses (0.1-0.9 mmol/kg), and was the most active agent evaluated at high doses, producing tumour growth delays of up to 9 days when combined with 10 mg/kg CCNU.
Did not alter tumour response when mouse body temperature was maintained.
Animal Model: C57Bl/Cbi (female, 2-3 months old, subcutaneous implantation of Lewis lung carcinoma cells)[2]
Dosage: 1.0 μmol/g; 2.0 μmol/g
Administration: i.p.; single dose; 20 minutes before cyclophosphamide
Result: Reduced the surviving fraction per gram of tumor relative to cyclophosphamide alone.
Animal Model: C3H/He (male and female, 12-16 weeks old, 20-28 g, intramuscularly grown RIF-1 sarcoma model)[3]
Dosage: 1 mmol/kg
Administration: i.p.; single dose; 30 minutes prior to chlorambucil
Result: Produced a tumor growth delay of 8.4 days when combined with 7.5 mg/kg chlorambucil.
Produced a tumor growth delay of 13.9 days when combined with 7.5 mg/kg chlorambucil.
Was at least as effective as 2.5 mmoles/kg misonidazole in enhancing chlorambucil's antitumor effect.
Molecular Weight

227.22

Formula

C9H13N3O4
CAS No.
SMILES

OC(CN1C=CN=C1[N+]([O-])=O)CO/C=C/C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ro 07-1902 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 07-190268160-71-4Otherssarcoma cellsLewis lung carcinomachlorambucilcarcinoma cellsKHT sarcomaCCNUC3H/He miceRIF-1 mouse sarcomacyclophosphamideKHT fibrosarcoma modelInhibitorinhibitorinhibit

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