68160-71-4
68160-71-4
Chemical Structure
Ro 07-1902
- CAS No.: 68160-71-4
- Formula:C9H13N3O4
- Molecular Weight:227.22
IUPAC Name: (E)-1-(2-nitro-1H-imidazol-1-yl)-3-(prop-1-en-1-yloxy)propan-2-ol
InChIKey: XVAVDAAXADYTPR-GORDUTHDSA-N
SMILES: OC(CN1C=CN=C1[N+]([O-])=O)CO/C=C/C
Biological Activity: Ro 07-1902 is a potent antitumor synergist. Ro 07-1902 enhances the antitumor effects of CCNU (HY-13669), Chlorambucil (HY-13593) and Cyclophosphamide (HY-17420). Ro 07-1902 exhibits no single-agent cytotoxicity and does not delay tumor growth. Ro 07-1902 can be used in research related to various cancers[1][2][3].
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Ro 07-1902 | Ro 07-1902 is a potent antitumor synergist. Ro 07-1902 enhances the antitumor effects of CCNU (HY-13669), Chlorambucil (HY-13593) and Cyclophosphamide (HY-17420). Ro 07-1902 exhibits no single-agent cytotoxicity and does not delay tumor growth. Ro 07-1902 can be used in research related to various cancers. | |||||||||||||||||||||
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References
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[1]. Workman P, Twentyman PR. Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU. Br J Cancer. 1982;46(2):249–259.
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[2]. Chaplin DJ, et al. Potentiation of cyclophosphamide cytotoxicity in vivo: a study with misonidazole and fifteen other 1-substituted 2-nitroimidazoles. Int J Radiat Oncol Biol Phys. 1984;10(9):1647–1651.
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[3]. Twentyman PR, Workman P. The effect of radiosensitizer pretreatment on the response of the RIF-1 mouse sarcoma to cytotoxic drugs. Int J Radiat Oncol Biol Phys. 1982;8(3–4):611–613.
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