Search Result

Results for "

relieving pain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) ADAMTS (1) Adenosine Receptor (1) Adrenergic Receptor (7) Akt (3) Aldehyde Dehydrogenase (ALDH) (2) AMPK (1) Apoptosis (15) Autophagy (3) Bacterial (4) Biochemical Assay Reagents (3) Calcium Channel (12) Carbonic Anhydrase (1) Caspase (2) Cholecystokinin Receptor (3) Cholinesterase (ChE) (1) COX (13) Cytochrome P450 (2) DNA/RNA Synthesis (1) Drug Derivative (3) Drug Metabolite (2) Endogenous Metabolite (3) Environmental Pollutants (2) Ephrin Receptor (3) ERK (4) Estrogen Receptor/ERR (1) Ferroptosis (3) Fungal (2) GABA Receptor (5) Glucocorticoid Receptor (3) Glutathione Peroxidase (1) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (4) Histone Methyltransferase (2) iGluR (8) Interleukin Related (5) Isotope-Labeled Compounds (9) MEK (1) mTOR (1) Na+/K+ ATPase (1) nAChR (2) Neuropeptide Y Receptor (1) NF-κB (3) NO Synthase (1) Opioid Receptor (6) P2X Receptor (4) p38 MAPK (2) Parasite (1) PERK (1) PGE synthase (1) Phosphodiesterase (PDE) (1) PKC (2) PPAR (1) Prostaglandin Receptor (5) Reference Standards (22) Ser/Thr Protease (1) Serotonin Transporter (4) Sigma Receptor (1) Sodium Channel (9) STAT (1) TNF Receptor (1) Topoisomerase (1) TRP Channel (2) VEGFR (3) α-synuclein (2) β-catenin (1) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (9) Endocrinology (5) Infection (6) Inflammation/Immunology (41) Metabolic Disease (7) Neurological Disease (68)

By Targets:

5-HT Receptor (1)

ADAMTS (1)

Adenosine Receptor (1)

Adrenergic Receptor (7)

Akt (3)

Aldehyde Dehydrogenase (ALDH) (2)

AMPK (1)

Apoptosis (15)

Autophagy (3)

Bacterial (4)

Biochemical Assay Reagents (3)

Calcium Channel (12)

Carbonic Anhydrase (1)

Caspase (2)

Cholecystokinin Receptor (3)

Cholinesterase (ChE) (1)

COX (13)

Cytochrome P450 (2)

DNA/RNA Synthesis (1)

Drug Derivative (3)

Drug Metabolite (2)

Endogenous Metabolite (3)

Environmental Pollutants (2)

Ephrin Receptor (3)

ERK (4)

Estrogen Receptor/ERR (1)

Ferroptosis (3)

Fungal (2)

GABA Receptor (5)

Glucocorticoid Receptor (3)

Glutathione Peroxidase (1)

HIF/HIF Prolyl-Hydroxylase (4)

Histamine Receptor (4)

Histone Methyltransferase (2)

iGluR (8)

Interleukin Related (5)

Isotope-Labeled Compounds (9)

MEK (1)

mTOR (1)

Na+/K+ ATPase (1)

nAChR (2)

Neuropeptide Y Receptor (1)

NF-κB (3)

NO Synthase (1)

Opioid Receptor (6)

P2X Receptor (4)

p38 MAPK (2)

Parasite (1)

PERK (1)

PGE synthase (1)

Phosphodiesterase (PDE) (1)

PKC (2)

PPAR (1)

Prostaglandin Receptor (5)

Reference Standards (22)

Ser/Thr Protease (1)

Serotonin Transporter (4)

Sigma Receptor (1)

Sodium Channel (9)

STAT (1)

TNF Receptor (1)

Topoisomerase (1)

TRP Channel (2)

VEGFR (3)

α-synuclein (2)

β-catenin (1)

γ-Glutamyl Transferase (GGT) (1)

By Research Areas:

Cancer (41)

Cardiovascular Disease (9)

Endocrinology (5)

Infection (6)

Inflammation/Immunology (41)

Metabolic Disease (7)

Neurological Disease (68)

117

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0057

Gabapentin 10+ Cited Publications	Calcium Channel	Neurological Disease Cancer
Gabapentin is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain .

HY-122272

Paroxetine Maximum Cited Publications 17 Publications Verification BRL29060	Serotonin Transporter Adrenergic Receptor P2X Receptor Apoptosis	Neurological Disease Cancer
Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0193

Prazosin 15+ Cited Publications	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease .

HY-17444

Tesaglitazar	PPAR	Metabolic Disease Cancer
Tesaglitazar is a dual-target PPARα/γ agonist with an EC₅₀ of 13.4 μM for rat PPARα and 3.6 μM for human PPARα. Tesaglitazar affects lipid and glucose metabolism by activating PPARα and PPARγ receptors, and has the potential to improve blood sugar and relieve pain. Tesaglitazar can be used to induce in vivo tumor models and can be used in the study of type 2 diabetes, dyslipidemia, and neuropathic pain .

HY-76711

Naltrexone	Opioid Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight .

HY-B0444

Maprotiline hydrochloride 4 Publications Verification	Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 .

HY-111613

Pinaverium bromide 4 Publications Verification	Calcium Channel	Cancer
Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .

HY-B0364A

Dyclonine hydrochloride 1 Publications Verification Dyclocaine hydrochloride	Bacterial Fungal Aldehyde Dehydrogenase (ALDH)	Infection Cancer
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC₅₀ of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain .

HY-13681

Methylprednisolone acetate 1 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology
Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-B0369A

Orphenadrine citrate	iGluR	Neurological Disease Cancer
Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-A0057A

Gabapentin hydrochloride 10+ Cited Publications	Calcium Channel	Neurological Disease Cancer
Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain .

HY-B1279

Metamizole sodium hydrate 2 Publications Verification Dipyrone hydrate; Methamizole sodium hydrate	COX Apoptosis	Inflammation/Immunology
Metamizole sodium hydrate (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor.. Metamizole sodium hydrate can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium hydrate has anti-inflammatory and antioxidant activities. Metamizole sodium hydrate is an antipyretic, analgesic and spasmolytic agent. Metamizole sodium hydrate can be used in research to relieve a variety of pain .

HY-107150

Reproxalap ADX-102; NS-2	PKC Caspase	Neurological Disease Inflammation/Immunology
Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis .

HY-B1279A

Metamizole sodium 2 Publications Verification Dipyrone; Methamizole sodium	COX Apoptosis	Inflammation/Immunology Cancer
Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain .

HY-B0641

Felbinac 4-Biphenylacetic acid	COX	Inflammation/Immunology
Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC₅₀ of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity .

HY-110292

A-425619	TRP Channel Calcium Channel	Inflammation/Immunology
A-425619 is an orally active and selective transient receptor potential type V1 (TRPV1) antagonist. A-425619 blocks Capsaicin (HY-10448)- and N-arachidonoyl-dopamine (NADA)-induced Ca ²⁺ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury .

HY-139644

MIPS521	Adenosine Receptor	Neurological Disease
MIPS521 is a positive allosteric modulator of adenosine A₁ receptor (A₁AR). MIPS521 also has a lower A₁R allosteric affinity (pK_B=4.95; K_B=11 μM). MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine .

HY-B0714

Dexketoprofen (trometamol) 2 Publications Verification Dexketoprofen tromethamine salt	COX	Neurological Disease Inflammation/Immunology Cancer
Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect .

HY-B0653A

Levobupivacaine hydrochloride 2 Publications Verification (S)-(-)-Bupivacaine monohydrochloride	Sodium Channel Ferroptosis	Cardiovascular Disease Neurological Disease Cancer
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-105584

Tolycaine	Biochemical Assay Reagents	Neurological Disease
Tolycaine is a local agent that can suppress or relieve pain. Tolycaine also induces a convulsive response in experimental animals .

HY-N7074

Lanolin	Environmental Pollutants Bacterial	Inflammation/Immunology Cancer
Lanolin is a yellow fat that can be extracted from wool. Lanolin can be used as a skin moisturizer and applied topically to relieve nipple pain and chapping during lactation .

HY-13283

MF63 1 Publications Verification	PGE synthase	Inflammation/Immunology
MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE₂, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1 .

HY-N0688

Linderane	Cytochrome P450	Inflammation/Immunology
Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp .

HY-120824

Mofezolac 2 Publications Verification	COX	Inflammation/Immunology
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC₅₀ of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC₅₀ of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities .

HY-145558

Bliretrigine	Sodium Channel	Neurological Disease
Bliretrigine is a sodium channel blocker. Bliretrigine has the effect of relieving pain .

HY-108707

LY3130481 1 Publications Verification	iGluR	Neurological Disease
LY3130481 is an orally available AMPA receptor antagonist, selectively inhibiting the IC₅₀ value of AMPA/TARP γ-8 at 65 nM. LY3130481 has anticonvulsant, antiepileptic, and pain-relieving effects .

HY-W357818

Glycinexylidide GX	Sodium Channel ERK MEK NF-κB Drug Metabolite	Cancer
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease .

HY-B0971

Pheniramine maleate Prophenpyridamine maleate; Tripoton maleate	Histamine Receptor Apoptosis	Inflammation/Immunology Endocrinology
Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-76711S

Naltrexone-d4	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Naltrexone-d4 is deuterium labeled Naltrexone (HY-76711). Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight.

HY-B2080A

Etidocaine hydrochloride 2 Publications Verification EDC hydrochloride	Sodium Channel	Infection Others
Etidocaine (hydrochloride) is a long aminoamide local agent that can suppress or relieve pain .

HY-108068

Alphadolone acetate Alfadolone acetate; GR 2/1574	GABA Receptor	Neurological Disease
Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception .

HY-109547

Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine	COX	Inflammation/Immunology Cancer
Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID) . Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies .

HY-108562

SC-51322	Prostaglandin Receptor	Neurological Disease
SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE₂) receptor (EP ₁), with a pA₂ of 8.1. SC-51322 has the pain-relieving effect .

HY-B1726

Phenacaine Holocaine	Phosphodiesterase (PDE)	Metabolic Disease
Phenacaine (Holocaine) is a local agent that can suppress or relieve pain. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca ²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .

HY-B0444R

Maprotiline hydrochloride (Standard) 4 Publications Verification	Reference Standards Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline (hydrochloride) (Standard) is the analytical standard of Maprotiline (hydrochloride). Maprotiline (hydrochloride) (Standard) is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline (hydrochloride) (Standard) induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 .

HY-103520

DS2	GABA Receptor	Neurological Disease
DS2 is a selective positive allosteric modulator of δ-GABA_A receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research .

HY-W275039

Phenylquinone 2-Phenylbenzoquinone	Biochemical Assay Reagents	Neurological Disease
Phenylquinone (2-Phenylbenzoquinone) causes pain and induces writhing in mice, and is often used in experiments to test the effectiveness of analgesics or agent that can suppress or relieve pain .

HY-B1126

Orphenadrine hydrochloride	iGluR	Neurological Disease Cancer
Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-B0444A

Maprotiline	Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 .

HY-B0653

Levobupivacaine 2 Publications Verification (S)-(-)-Bupivacaine	Sodium Channel Ferroptosis	Neurological Disease Cancer
Levobupivacaine ((S)-(-)-Bupivacaine) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-W121901

Naproxen glucuronide (S)-Naproxen-β-D-glucuronide	COX	Inflammation/Immunology
Naproxen glucuronide ((S)-Naproxen-β-D-glucuronide) is a non-selective COX inhibitor. Naproxen glucuronide, a metabolite of naproxen, is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same as ibuprofen) that relieves pain, fever, swelling, and stiffness .

HY-106407

Beloxepin Org 4428; ADL 6906	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects .

HY-76711R

Naltrexone (Standard)	Reference Standards Opioid Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Naltrexone (Standard) is the analytical standard of Naltrexone (HY-76711). This product is intended for research and analytical applications. Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight.

HY-A0057S

Gabapentin-d4	Calcium Channel	Neurological Disease
Gabapentin-d₄ is the deuterium labeled Gabapentin. Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.

HY-116457

Propanidid Sombrevin; Fabantol	GABA Receptor	Cardiovascular Disease Neurological Disease
Propanidid (Sombrevin; Fabantol) is a γ-aminobutyric acid type A (GABA_A) receptor agonist and a short-acting non-barbiturate general agent that can suppress or relieve pain. Propanidid can decrease the arterial pressure .

HY-107320

Amtolmetin guacil	Prostaglandin Receptor COX NO Synthase	Inflammation/Immunology
Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis .

HY-B0971A

Pheniramine Prophenpyridamine; Tripoton; Pheniramine solution	Histamine Receptor Apoptosis	Inflammation/Immunology Cancer
Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-W005637

Orthocaine	Others	Neurological Disease
Orthocaine is a local agent that can suppress or relieve pain (extracted from patent WO2002089849A1) .

HY-B1656

Fomocaine P 652	Sodium Channel	Cardiovascular Disease Neurological Disease
Fomocaine (P 652) is an orally active local agent that can suppress or relieve pain. Fomocaine shows antiarrhythmic activity .

HY-139068

Ibuprofen arginine	Drug Derivative	Others
Ibuprofen arginine is an orally active L-arginine of Ibuprofen (HY-78131). With rapid absorption and high bioavailability, Ibuprofen arginine can effectively relieve a variety of acute pain, and has little damage to gastric mucosa and is well tolerated. Ibuprofen arginine can be used in research for pain relief .

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library

217 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 217 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Cat. No.	Product Name	Type

HY-D0914

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Fluorescent Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function .

HY-D0914A

Fast green FCF free acid

Fluorescent Dyes

Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function .

Cat. No.	Product Name	Target	Research Area

HY-P1130

M871 Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .

HY-P2428

RI-61	Endogenous Metabolite	Neurological Disease
RI-61 is a compound that has activity in suppressing migraine, cluster headache, new daily persistent headache and cyclical vomiting syndrome. RI-61 has shown significant efficacy in relieving the symptoms of these disorders. RI-61 helps relieve pain and other related symptoms by modulating the action of neurotransmitters .

HY-P11249

Mr1.1[S4Dap, C16Pen]	nAChR	Neurological Disease
Mr1.1[S4Dap, C16Pen] is a highly active and selective nAChR (human α9α10 nAChR IC₅₀ = 4.0 nM, rat α9α10 nAChR IC₅₀ = 2.7 nM) inhibitor. Mr1.1[S4Dap, C16Pen] can significantly relieve pain and has significant stability. Mr1.1[S4Dap, C16Pen] can be used for the study of neuropathic pain .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992358

GSK2394002	ADAMTS	Cardiovascular Disease
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0193

Prazosin 15+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease .

HY-N7074

Lanolin	Structural Classification Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Bacterial
Lanolin is a yellow fat that can be extracted from wool. Lanolin can be used as a skin moisturizer and applied topically to relieve nipple pain and chapping during lactation .

HY-N0688

Linderane	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450
Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp .

HY-N4280

7,8-Dimethoxycoumarin 1 Publications Verification	Structural Classification Classification of Application Fields Rutaceae Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Source Classification	Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H ⁺/K ⁺-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .

HY-155236

Ancistrotecine B	Alkaloids Piperidine Alkaloids Ancistrocladus tectorius (Lour.) Merr. Plants Ancistrocladaceae Source Classification	Sodium Channel
Ancistrotecine B (Compound 2) is a Nav1.7 channel inhibitor (IC₅₀: 0.73 μM). Ancistrotecine B relieves inflammatory pain in mice .

HY-N7748A

Epi-cryptoacetalide	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Estrogen Receptor/ERR Prostaglandin Receptor
Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to ER-α and PGE2 receptor (EP2 subtype) with K_i values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities .

HY-N7513R

Homovanillyl alcohol (Standard)	Structural Classification Monophenols other families Phenols Plants Source Classification	TNF Receptor Reference Standards Drug Metabolite
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-N0688R

Linderane (Standard)	Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Source Classification	Reference Standards Cytochrome P450
Linderane (Standard) is the analytical standard of Linderane. This product is intended for research and analytical applications. Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp .

HY-W016586R

Acivicin (Standard) AT-125 (Standard); U-42126 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Parasite γ-Glutamyl Transferase (GGT)
Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway .

HY-N7814R

2-Hydroxypalmitic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Endogenous Metabolite
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-N18818

Arnica oil	Structural Classification Extract	Others
Arnica oil can be used to relieve symptoms of inflammation and pain.

HY-N16747

Excavatin G	Structural Classification Flavonoids Rutaceae Plants Other Flavonoids Clausena excavata N. L. Burman Source Classification	Others
Excavatin G is a novel coumarin compound that can be isolated from Clausena excavata. While the Clausena excavata plant itself has traditional uses such as insecticidal properties and relieving stomach pain, the specific key activities and functions of Excavatin G require targeted research and verification .

HY-W800535

Cryptolepine	Malvaceae Structural Classification Alkaloids Sida acuta Burm. F. Quinoline Alkaloids Plants Indole Alkaloids Source Classification	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection .

Cat. No.	Product Name	Chemical Structure

HY-76711S

Naltrexone-d4

Naltrexone-d4 is deuterium labeled Naltrexone (HY-76711). Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight.

HY-A0057S

Gabapentin-d4
Gabapentin-d₄ is the deuterium labeled Gabapentin. Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.

HY-111613S

Pinaverium bromide-d4
Pinaverium bromide-d₄ is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .

HY-W011777S

Tricaine-d5 methanesulfonate

Tricaine-d₅ methanesulfonate is the deuterium labeled Tricaine methanesulfonate (HY-W011777). Tricaine methanesulfonate (MS-222) is a commonly used agent that can suppress or relieve pain. agent for immobilization of aquatic species. Tricaine methanesulfonate, the most widely used agent that can suppress or relieve pain. in fish, has been shown to induce embryotoxic effects in zebrafish .

HY-13681S

Methylprednisolone acetate-d6
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-B1126S

Orphenadrine-d3 hydrochloride

Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride . Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-B0653AS

Levobupivacaine-d9 hydrochloride

Levobupivacaine-d₉ ((S)-(–)-Bupivacaie-d₉) hydrochloride is deuterium labeled Levobupivacaine hydrochloride (HY-B0653A). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

HY-W721517

Gabapentin-d10
Gabapentin-d₁₀ is the deuterium labeled Gabapentin (HY-A0057). Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain .

HY-A0057AS2

Gabapentin-d4 hydrochloride
Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain .

HY-111124

Paroxetine-d2

Paroxetine-d₂ (CTP 347) is a deuterium labeled Paroxetine (HY-122272). Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

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