504 Results for "

secondary

" in MedChemExpress (MCE) Product Catalog:
Products (504)

504 Results for "secondary" in MCE Product Catalog:

30
30 Publications Verification
Cat. No.: HY-13771
CAS No.: 128-13-2
Purity:  99.94%
Synonyms: Ursodeoxycholate; Ursodiol; UDCA
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active .
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30
30 Publications Verification
Cat. No.: HY-13771A
CAS No.: 2898-95-5
Purity:  99.06%
Synonyms: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium
Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .
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21
21 Cited Publications
Cat. No.: HY-B0172
CAS No.: 434-13-9
Synonyms: 3α-Hydroxy-5β-cholanic acid
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .
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16
16 Cited Publications
Cat. No.: HY-50919
CAS No.: 131918-61-1
Target:  

VD/VDR

Research Areas:  

Metabolic Disease Cancer

Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
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12
12 Cited Publications
Cat. No.: HY-B0312
CAS No.: 58-32-2
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis .
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11
11 Cited Publications
Cat. No.: HY-12355A
CAS No.: 1234627-85-0
Purity:  99.64%
Synonyms: BAF-312 hemifumarate
Siponimod (BAF-312) hemifumarate is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod hemifumarate induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod hemifumarate can be used in research related to multiple sclerosis .
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10
10 Cited Publications
Cat. No.: HY-108477
CAS No.: 36951-72-1
Purity:  ≥98.0%
Synonyms: TMP 1363
Research Areas:  

Cancer

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .
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10
10 Cited Publications
Cat. No.: HY-W112938
CAS No.: 92739-63-4
TMPyP tetrachloride is a quadruplex-specific ligand. TMPyP tetrachloride inhibits the interaction between G-quadruplexes and IGF-1. TMPyP tetrachloride is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP tetrachloride is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP tetrachloride has antiviral activity against SARS-CoV-2 .
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8
8 Cited Publications
Cat. No.: HY-N0147
CAS No.: 84-26-4
Synonyms: Rutecarpine
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. Rutaecarpine can target and activate the NRF2/HO-1 pathway to reduce craniofacial injury. Rutaecarpine sttenuates oxidative stress-induced traumatic brain injury (TBI) and reduces secondary injury via the PGK1/KEAP1/NRF2 signaling pathway. Rutaecarpine can cross the blood-brain barrier (BBB).
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7
7 Cited Publications
Cat. No.: HY-109192
CAS No.: 1971920-73-6
Purity:  99.79%
Synonyms: SAR442168; PRN2246
Target:  

Btk

Tolebrutinib (SAR442168) is an orally active, selective, and blood-brain barrier-penetrant BTK inhibitor with neuroactive properties. Tolebrutinib is being investigated for use in multiple sclerosis (MS), particularly secondary progressive multiple sclerosis (SPMS). .
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6
6 Cited Publications
Cat. No.: HY-117695
CAS No.: 148757-94-2
Purity:  ≥95.0%
Synonyms: 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels .
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6
6 Cited Publications
Cat. No.: HY-N0169
CAS No.: 83-49-8
Synonyms: HDCA
Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
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6
6 Cited Publications
Cat. No.: HY-N0169A
CAS No.: 10421-49-5
Synonyms: HDCA sodium
Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells .
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6
6 Cited Publications
Cat. No.: HY-101884
CAS No.: 576-19-2
Purity:  99.91%
Synonyms: (+)-Biocytin
Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays .
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3
3 Cited Publications
Cat. No.: HY-116374A
CAS No.: 24404-83-9
Purity:  ≥98.0%
Synonyms: Lithocholylglycine sodium
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Glycolithocholic acid (Lithocholylglycine) sodium is the sodium salt of Glycolithocholic acid. Glycolithocholic acid is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .
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3
3 Cited Publications
Cat. No.: HY-100711
CAS No.: 82-89-3
Purity:  99.89%
Synonyms: Prodigiosine; NSC47147
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
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3
3 Cited Publications
Cat. No.: HY-116374
CAS No.: 474-74-8
Purity:  99.90%
Synonyms: Lithocholylglycine
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .
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3
3 Cited Publications
Cat. No.: HY-100711A
CAS No.: 56144-17-3
Purity:  98.00%
Synonyms: Prodigiosine hydrochloride
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
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3
3 Cited Publications
Cat. No.: HY-B0141S1
CAS No.: 66789-03-5
Synonyms: β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4
Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
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2
2 Cited Publications
Cat. No.: HY-107846
CAS No.: 9014-63-5
Purity:  ≥95.0%
Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose .
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