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sorbitol dehydrogenase

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By Targets:	Aldehyde Dehydrogenase (ALDH) (4) Biochemical Assay Reagents (2) Endogenous Metabolite (2) Environmental Pollutants (1)
By Research Areas:	Metabolic Disease (7) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118980

Sorbitol dehydrogenase-IN-1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Sorbitol dehydrogenase-IN-1 is a potent and orally active **sorbitol dehydrogenase inhibitor with IC₅₀** s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol .

HY-B0400B

D-Sorbitol, for cell culture Sorbito, for cell culture; D-Glucitol, for cell culture	Environmental Pollutants Biochemical Assay Reagents	Others
D-Sorbitol (D-Glucitol), for cell culture is a six-carbon sugar alcohol that can be used as a sugar substitute. D-Sorbitol, for cell culture serves as an osmotic regulator, cryoprotectant and carbon source in various plant and microbial cell culture media .

HY-E70398

**Sorbitol dehydrogenase** L-Iditol dehydrogenase; Polyol dehydrogenase; SDH	Biochemical Assay Reagents	Metabolic Disease
Sorbitol dehydrogenase (L-Iditol dehydrogenase) is an oxidoreductasea and catalyses the conversion of sorbitol to fructose with NAD ⁺ as the coenzyme. Sorbitol dehydrogenase catalyses pH-dependent redox reactions between NAD ⁺/NADH and sorbitol/fructose. Sorbitol dehydrogenase is implicated in diabetic complications and is a biomarker of drug-induced liver injury. Sorbitol dehydrogenase can be used for the research of diabetes and liver injury .

HY-164605

(6S)-CP-470711	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
(6S)-CP-470711 (Compound 8) is an inhibitor for **sorbitol dehydrogenase, that inhibits human and rat SDH with IC₅₀** of 19 nM and 27 nM. (6S)-CP-470711 ameliorates the Streptozotocin (HY-13753)-induced diabetes in rats models .

HY-E70407

Sorbitol-6-phosphate 2-dehydrogenase, escherichia coli 1-5-Anhydroglucitol-6-phosphate dehydrogenase, escherichia coli	Endogenous Metabolite	Metabolic Disease
Sorbitol-6-phosphate 2-dehydrogenase, escherichia coli is a dehydrogenase produced by E. coli. Sorbitol-6-phosphate 2-dehydrogenase, escherichia coli can catalyze the conversion between D-sorbitol 6-phosphate and D-fructose 6-phosphate, with the oxidation of D-sorbitol 6-phosphate happening at a rate 10 times faster than the reduction of D-fructose 6-phosphate, and it plays a role in various cellular processes .

HY-164698

CP-470711	Aldehyde Dehydrogenase (ALDH)	Neurological Disease Metabolic Disease
CP-470711 is an orally active and potent and selective sorbitol dehydrogenase (SDH) inhibitor with an IC₅₀=10 nM for human SDH and IC₅₀=17 nM for rat SDH. CP-470711 is promising for research of chronic complications related to type 2 diabetes mellitus, such as neuropathy and nephropathy .

HY-E70398A

Sorbitol Dehydrogenase, Sheep	Endogenous Metabolite	Metabolic Disease
Sorbitol dehydrogenase, Sheep (EC 1.1.1.14) is an enzyme in carbohydrate metabolism that converts sorbitol, the sugar alcohol form of glucose, into fructose. Sorbitol dehydrogenase works in conjunction with aldose reductase, enabling the body to utilize glucose to produce fructose without ATP consumption. Sorbitol dehydrogenase uses NAD+ as a cofactor, and zinc ions also participate in the catalytic process.

HY-N15464

Antihepatotoxic agent-1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and **sorbitol dehydrogenase** from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

D-Sorbitol, for cell culture Sorbito, for cell culture; D-Glucitol, for cell culture	Biochemical Assay Reagents
D-Sorbitol (D-Glucitol), for cell culture is a six-carbon sugar alcohol that can be used as a sugar substitute. D-Sorbitol, for cell culture serves as an osmotic regulator, cryoprotectant and carbon source in various plant and microbial cell culture media .

Antihepatotoxic agent-1	Structural Classification Solanaceae Plants Lycium chinense Miller Saccharides Monosaccharides Source Classification	Aldehyde Dehydrogenase (ALDH)
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and **sorbitol dehydrogenase** from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71328

	SORD Protein, Human (HEK293, His) sorbitol dehydrogenase; L-Iditol 2-dehydrogenase; SORD	Human	HEK293
	SORD Protein is an enzyme that in humans is encoded by the SORD gene. SPRD is a polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. SPRD is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. SORD Protein, Human (HEK293, His) is the recombinant human-derived SORD protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	ICC/IF (2) WB (2) FC (2)
Isotype:	IgG2a (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

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HY-P88311

	*SORD (Sorbitol* Dehydrogenase) Antibody (YA7995)** HEL-S-95n; SORD1	WB, ICC/IF, FC	Human
	SORD (Sorbitol Dehydrogenase) Antibody (YA7995) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SORD (Sorbitol Dehydrogenase).

HY-P88311A

	*SORD (Sorbitol* Dehydrogenase) Antibody (YA7995)(PBS only)** HEL-S-95n; SORD1	WB, ICC/IF, FC	Human
	SORD (Sorbitol Dehydrogenase) Antibody (YA7995) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SORD (Sorbitol Dehydrogenase).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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