Segigratinib hydrochloride
Segigratinib hydrochloride (3D185) is a potent inhibitor of FGFR1/2/3 and CSF-1R; The IC50 values for FGFR1, FGFR2, FGFR3 and CSF-1R are 0.5, 1.3, 3.6 and 3.8 nM, respectively. Segigratinib hydrochloride has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2847066-15-1
- Formula: C27H29Cl3N6O3
- Molecular Weight:591.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FGFR1 0.5 nM (IC50) |
FGFR2 1.3 nM (IC50) |
FGFR3 3.6 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2847066-15-1
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Molecular Weight 591.92
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Formula C27H29Cl3N6O3
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SMILES
O=C(C1=CC=C(N2CCNC(C)(C2)C)C=C1)NC3=NNC4=C3C=CC(C5=C(Cl)C(OC)=CC(OC)=C5Cl)=N4.Cl
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Synonyms
3D185; HH185
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Segigratinib hydrochloride Related Classifications
HY-159503A Related Classifications
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