2. Stem Cell/Wnt
  3. Smo
  4. SMO-IN-1

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh).

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SMO-IN-1

SMO-IN-1 Chemische Struktur

CAS. Nr. : 1126365-66-9

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SMO-IN-1 Related Antibodies

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Beschreibung

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh)[1].

Cellular Effect
Cell Line Type Value Description References
C3H 10T1/2 EC50
0.089 μM
Compound: 11g
Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis
Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis
[PMID: 22704236]
C3H 10T1/2 EC50
89 nM
Compound: 15
Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs
Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs
[PMID: 31862310]
NIH3T3 IC50
0.005 μM
Compound: 11g
Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay
Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay
[PMID: 22704236]
Molekulargewicht

398.46

Formel

C24H22N4O2
CAS. Nr.
SMILES

CC1=CC=C(C=C1NC(C2=CC=C(C=C2)OCC3=NC=CC=C3)=O)C4=CN(C=N4)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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SMO-IN-1 Related Classifications

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-11126365-66-9SmoSmoothenedmetastasized basal cell carcinomaantitumorsonic Hh proteinshhInhibitorinhibitorinhibit

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