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Cat. No.: HY-P2167

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Somatostatin RC-102

Somatostatin RC-102 is an octapeptide analog of Somatostatin. Somatostatin RC-102 inhibits the release of growth hormone and insulin. Somatostatin RC-102 enhances the inhibition of cell migration by increasing the production or activity of LMIF, but exerts no effect on cell migration in the absence of exposure to cardiac antigens or phytohemagglutinin. Somatostatin RC-102 inhibits gastric acid secretion. Somatostatin RC-102 can be used in the research of heart diseases.

For research use only. We do not sell to patients.

CAS No.: 99685-66-2
Formula: C₄₉H₆₅N₁₁O₁₀S₂
Molecular Weight:1032.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Somatostatin RC-102 Chemical Structure

CAS No.: 99685-66-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Somatostatin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	>1 μM Compound: 1	Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst1 receptor expressed in CHOK1 cells by autoradiography Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst1 receptor expressed in CHOK1 cells by autoradiography	[PMID: 18410083]
CHO-K1	IC₅₀	1000 nM Compound: 1	Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst1 receptor expressed in CHOK1 cells by autoradiography Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst1 receptor expressed in CHOK1 cells by autoradiography	[PMID: 18410083]
CHO-K1	IC₅₀	5.1 nM Compound: 1	Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst5 receptor expressed in CHOK1 cells by autoradiography Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst5 receptor expressed in CHOK1 cells by autoradiography	[PMID: 18410083]

In Vivo

Somatostatin RC-102 (0.02-0.08 μg/100 g body weight; s.c.; single dose) is 45 times more potent than somatostatin-14 in inhibiting in vivo GH release in anesthetized male Sprague-Dawley rats^[2].
Somatostatin RC-102 (i.v.; single dose) is 38 times more potent than somatostatin-14 in inhibiting in vivo insulin release in fasted, anesthetized male Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 200-350 g, anesthetized)^[2]
Dosage:

0.02 μg/100 g body weight; 0.08 μg/100 g body weight
Administration:

s.c.; single dose
Result:

Reduced plasma GH levels to 143 ng/mL at 0.02 μg/100 g body weight (vs. saline control 427 ng/mL).
Reduced plasma GH levels to 69 ng/mL at 0.08 μg/100 g body weight.
Exhibited 45 times more potency than somatostatin-14 in inhibiting GH release, with a potency value of 4500% relative to somatostatin-14.

Chemical Information

CAS No. 99685-66-2
Molecular Weight 1032.25
Formula C₄₉H₆₅N₁₁O₁₀S₂
SMILES

C(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC([C@@H](CC5=CC=CC=C5)N)=O)CSSC[C@@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCCCN)NC3=O)[H]
Sequence

{d-Phe}-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

fCFwKTCT-NH2 (Disulfide bridge: Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pawlikowski M, et al. Somatostatin and its analog enhance the formation of human leukocyte migration inhibiting factor: further evidence for immunomodulatory action of somatostatin. Peptides. 1987;8(5):951-2.

[2]. Cai RZ, et al. Synthesis and biological activity of highly potent octapeptide analogs of somatostatin. Proceedings of the National Academy of Sciences of the United States of America. 1986 Mar;83(6):1896-900.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Somatostatin RC-102

All Somatostatin Receptor Isoforms