2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. SORT-PGRN interaction inhibitor 2

SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research.

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SORT-PGRN interaction inhibitor 2

SORT-PGRN interaction inhibitor 2 Chemische Struktur

CAS. Nr. : 1008233-79-1

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SORT-PGRN interaction inhibitor 2 Related Antibodies

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Beschreibung

SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research[1].

In Vitro

SORT-PGRN interaction inhibitor 2 (Compound MPEP) (0-20 μM; 24 hours) decreases SORT1 expression and increases extracellular PGRN secretion in mammalian cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SORT-PGRN interaction inhibitor 2 Related Antibodies

Western Blot Analysis[1]

Cell Line: M17 cells, lymphoblastoid cell lines (LCLs) and iPSCs neurons, LCLs from two FTD-GRN families( UBC17 and UBC15)
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Preferentially increased extracellular PGRN levels by suppressing or reducing intracellular SORT1 levels without affecting sortilin-related family members SORLA and SORCS1.
Made exPGRN levels in the heterozygous mutation carrier (GRN+/2-LCL) restored to a level comparable with the homozygous non-carrier (GRN+/+-LCL) in p.R418X mutation in family UBC17.
Made exPGRN levels in the UBC15 family restored to 80% of that of noncarrier GRN+/+-LCL levels.
Molekulargewicht

289.46

Formel

C19H31NO
CAS. Nr.
SMILES

CC1CN(CCOC2=CC(C)=CC=C2C(C)(C)C)CCC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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SORT-PGRN interaction inhibitor 2 Related Classifications

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Keywords:

SORT-PGRN interaction inhibitor 21008233-79-1Neurotensin ReceptorM17 cellslymphoblastoid cell lines (LCLs)cellular models of FTD-GRNsortilin– progranulin axisInhibitorinhibitorinhibit

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