Succinic acid tromethamine (Synonyms: Wormwood acid tromethamine)

Cat. No.: HY-N0420A: Data Sheet Handling Instructions
FAQs
Technical Support

Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries.

For research use only. We do not sell to patients.

CAS No. : 84540-64-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Succinic acid tromethamine:

THAM Succinic acid

Other Forms of Succinic acid tromethamine:

THAM In-stock
Succinic acid In-stock

7 Publications Citing Use of MCE Succinic acid tromethamine

•Water Air Soil Pollut. 232, 473 (2021).

RT-PCR

: Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant

: Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).

: Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.

: Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).

: Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]; Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[2]

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

Succinic acid tromethamine is derived from the fermentation of agricultural carbohydrates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Succinic acid tromethamine (3, 6 mg/kg; p.o.) increases the percentage of entries into open arms and of time spent on open arms in male mice^[3].
Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

239.22

Formula

C₈H₁₇NO₇

CAS No.

84540-64-7

SMILES

O=C(O)CCC(O)=O.OCC(CO)(N)CO

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]

[2]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii. [Content Brief]

[3]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. [Content Brief]

Succinic acid tromethamine Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Succinic acid84540-64-7Wormwood acidEndogenous Metaboliteanaerobicfermentationprecursoranxiolyticorally activeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *