Succinic acid tromethamine
Based on 8 publication(s) in Google Scholar
Succinic acid tromethamine is a potent and orally active anxiolytic agent. Succinic acid tromethamine is an intermediate product of the tricarboxylic acid cycle. Succinic acid tromethamine can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries.
For research use only. We do not sell to patients.
- CAS No.: 84540-64-7
- Formula: C8H17NO7
- Molecular Weight:239.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Succinic acid tromethamine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2026 Apr 15;20(8):101789. [Abstract]
- Cell Rep. 2026 Feb 25;45(3):117047. [Abstract]
- Inflamm Res. 2025 Nov 6;74(1):156. [Abstract]
- ACS Omega. 2024 Jun 14;9(26):28228-28236. [Abstract]
- Oncol Res. 2026 Jan 19;34(2):25. [Abstract]
- Water Air Soil Pollut. 232, 473 (2021).
Customer Validation & Images
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RT-PCR
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WB
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RT-PCR
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RT-PCR
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RT-PCR
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Succinic acid tromethamine is derived from the fermentation of agricultural carbohydrates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Succinic acid tromethamine (3, 6, 12 mg/kg; i.p.) significant increases in food intake during 5 min, and 40 min after drug administration rectal temperature was measured, succinic acid at a dose of 1.5 mg/kg, inhibited stress-induced hyperthermia[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 84540-64-7
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Molecular Weight 239.22
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Formula C8H17NO7
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SMILES
O=C(O)CCC(O)=O.OCC(CO)(N)CO
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Synonyms
Wormwood acid tromethamine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer. [Abstract]2023 May 10;31(5):781-797.e9. PMID: 37130518
Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant
Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).
Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.
Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).
Succinic acid tromethamine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]
Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).
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Cell Mol Gastroenterol Hepatol
Microbial Monotherapy With Leuconostoc sp LB-P8 Improves Inflammation and Fibrosis in Mouse Primary Sclerosing Cholangitis by Inhibiting Transforming Growth Factor β1/SMAD Signaling. [Abstract]2026 Apr 15;20(8):101789. PMID: 41997362 -
Cell Rep
Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis. [Abstract]2026 Feb 25;45(3):117047. PMID: 41746808 -
Inflamm Res
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury. [Abstract]2025 Nov 6;74(1):156. PMID: 41196309 -
ACS Omega
Highly Efficient Photoelectrochemical Detection of Cystatin C Based on a Core-Shell MOF Nanocomposite with Biomimetic-Catalysis Amplification. [Abstract]2024 Jun 14;9(26):28228-28236. PMID: 38973831 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
Purity & Documentation
References
[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]
[2]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii. [Content Brief]
[3]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Succinic acid tromethamine Related Classifications
HY-N0420A Related Classifications
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