SynB1
Based on 1 Customer Validation
SynB1 is a cell-penetrating peptide with blood-brain barrier permeability, derived from the antimicrobial peptide Protegrin 1. SynB1 enhances the cellular uptake efficiency and cytoplasmic localization level of conjugated constructs. SynB1 can be used in studies related to rabies and glioblastoma.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 1207092-86-1
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Formula:
C89H151N37
O27 - Molecular Weight:2171.38
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SynB1 can conjugate with rabies virus-neutralizing antibodies, and physically and chemically "pull" the neutralizing antibodies, which are originally blocked from entering the brain, into the brain, thereby achieving neutralization and clearance of the lethal rabies virus[1].
SynB1 enhances the delivery efficiency of a Notch inhibitory peptide (dnMAML) to glioblastoma cells and facilitates its penetration of the blood-brain barrier[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1207092-86-1
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Appearance Solid
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Molecular Weight 2171.38
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Formula C89H151N37
O27 -
Color White to light yellow
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Sequence
Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Arg-Arg-Arg-Phe-Ser-Thr-Ser-Thr-Gly-Arg-Ala
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Sequence Shortening
RGGRLSYSRRRFSTSTGRA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (46.05 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1].
Ren Z, et al. A SynB1-conjugated antibody cocktail crosses the blood-brain barrier to produce a therapeutic effect on rabies. Proc Natl Acad Sci U S A. 2025 Dec 30;122(52):e2516465122.
[Content Brief]
[2]. Opačak-Bernardi T, et al. Effects of cell penetrating Notch inhibitory peptide conjugated to elastin-like polypeptide on glioblastoma cells. J Drug Target. 2017;25(6):523-531. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4605 mL | 2.3027 mL | 4.6054 mL | 11.5134 mL |
| 5 mM | 0.0921 mL | 0.4605 mL | 0.9211 mL | 2.3027 mL | |
| 10 mM | 0.0461 mL | 0.2303 mL | 0.4605 mL | 1.1513 mL | |
| 15 mM | 0.0307 mL | 0.1535 mL | 0.3070 mL | 0.7676 mL | |
| 20 mM | 0.0230 mL | 0.1151 mL | 0.2303 mL | 0.5757 mL | |
| 25 mM | 0.0184 mL | 0.0921 mL | 0.1842 mL | 0.4605 mL | |
| 30 mM | 0.0154 mL | 0.0768 mL | 0.1535 mL | 0.3838 mL | |
| 40 mM | 0.0115 mL | 0.0576 mL | 0.1151 mL | 0.2878 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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