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Cat. No.: HY-187701

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TM-Cy-TBPA

TM-Cy-TBPA is a selective inhibitor of mammalian dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) with an IC₅₀ of 0.034 μM. TM-Cy-TBPA inhibits breast cancer cell proliferation via G2 phase arrest and apoptosis. TM-Cy-TBPA can be used for the research of metastatic breast cancer.

For research use only. We do not sell to patients.

Formula: C₄₇H₆₄F₃N₇O₁₄
Molecular Weight:1008.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TM-Cy-TBPA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	EC50	0.69 μM	Antiproliferative activity against human MCF-7 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human MCF-7 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
BT-474	EC50	0.48 μM	Antiproliferative activity against human BT-474 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human BT-474 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
BT-474	EC50	0.54 μM	Antiproliferative activity against human BT-474 Clone 5 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human BT-474 Clone 5 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
SK-BR-3	EC50	0.63 μM	Antiproliferative activity against human SKBr-3 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human SKBr-3 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
MDA-MB-468	EC50	0.65 μM	Antiproliferative activity against human MDA-MB-468 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human MDA-MB-468 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
MDA-MB-231	EC50	0.69 μM	Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246
MDA-MB-453	EC50	0.58 μM	Antiproliferative activity against human MDA-MB-453 breast cancer cells assessed as reduction in cell viability by WST-1 assay. Antiproliferative activity against human MDA-MB-453 breast cancer cells assessed as reduction in cell viability by WST-1 assay.	2026.07.28.741246

In Vitro

TM-Cy-TBPA (0-10 μM) potently and selectively inhibits human DPAGT1 with an IC₅₀ of 0.45 μM, shows no detectable activity against microbial lipid transferases, and exhibits no antibacterial activity^[1].
TM-Cy-TBPA inhibits the proliferation of breast cancer cell lines, including the triple-negative subtype cell lines MDA-MB-231 and MDA-MB-468, with EC₅₀ values ranging from 0.48 to 0.69 μM^[1].
TM-Cy-TBPA (0.1-10 μM; 6 h) induces extremely low levels of LDH leakage in MDA-MB-231 breast cancer cells even at concentrations as high as 10 μM, confirming that cell membrane integrity is preserved^[1].
TM-Cy-TBPA (0.1-10 μM; 24 h) induces G2 cell cycle arrest and mitochondria-mediated apoptosis in SKBr-3 and MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SKBr-3 and MDA-MB-231 cells
Concentration:

0.1, 0.25, 1.0, 2.5, 10 μM
Incubation Time:

24 h
Result:

Increased the levels of Cyclin B1, p-CDK1(Tyr15), Wee1, BiP/GRP78, XBP1s, CHOP, cytosolic cytochrome c, cleaved caspase-3/7, and cleaved PARP, while decreasing the levels of phospho-Histone H3(Ser10) and Bcl-2.

Chemical Information

Molecular Weight 1008.04
Formula C₄₇H₆₄F₃N₇O₁₄
SMILES

[H][C@@]1(O[C@H]2[C@H](NC(CNCC(C=C3)=CC=C3N(CC4)CCC4CNCC5=CC=C(OC(F)(F)F)C=C5)=O)CC[C@@H](C[C@@H](O)[C@@H]6[C@@H](O)[C@@H](O)[C@H](N7C(NC(C=C7)=O)=O)O6)C2)O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1NC(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kurosu M, et al. Rationally Engineered, Chemically Stable Tunicamycin Analogues Decouple DPAGT1 Inhibition from Non-Selective Toxicity. bioRxiv. 2026:2026-07.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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