Topoisomerase IIα-IN-10
Topoisomerase IIα-IN-10 (Compound 13r) is an inhibitor of Topoisomerase IIα. It binds to the active site of DNA when complexed with Topoisomerase IIα, and this binding is stabilized through interactions with DNA base pairs and amino acid residues. Topoisomerase IIα-IN-10 can induce Apoptosis by intercalating DNA and inhibiting Topoisomerase IIα, thereby disrupting the mitochondrial membrane potential and inhibiting the growth of HCT116 cell lines, with an IC50 of 4.37 μM against HCT116 cells. Topoisomerase IIα-IN-10 can be used for research in the field of cancer treatment.
For research use only. We do not sell to patients.
- Formula: C32H27N3O3
- Molecular Weight:501.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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Molecular Weight 501.58
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Formula C32H27N3O3
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SMILES
O=C1C(/C(C)=N/CC2=CC3=C(C(C4=CC=C(C(C)C)C=C4)=N2)NC5=C3C=CC=C5)=C(O)C6=C(O1)C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase IIα-IN-10 Related Classifications
HY-170557 Related Classifications
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