Tubulin-IN-61 

Tubulin-IN-61 is a tubulin polymerization inhibitor with an IC₅₀ of ≤7.63 μM. Tubulin-IN-61 induces early apoptosis and triggers significant G2/M phase arrest. Tubulin-IN-61 elevates intracellular ROS levels. Tubulin-IN-61 shows high activity against MCF-7 cells with an IC₅₀ of 5.61 μM. Tubulin-IN-61 can be used for the research of breast cancer^[1].

Tubulin-IN-61 (compound 14d) shows potent cytotoxic activity on MCF-7, MDA-MB-231, HepG2, and A549 cancer cell lines with IC₅₀ values of 5.61 μM, 18.86 μM, 21.78 μM, and 15.34 μM, respectively. Tubulin-IN-61 has high selectivity toward malignant over normal cells^[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) effectively induce G2/M phase arrest in a dose-dependent manner^[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) inhibits cell migration using a wound-healing assay on the MCF-7 breast cancer cell line^[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) induces apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

597.69

C₃₄H₂₇N₇O₂S

COC1=CC(C2=NC3=C(C=CC=C3)N2CC4=CN(N=N4)CC5=CC6=C(C(C7=CC=CS7)=N5)NC8=CC=CC=C86)=CC=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mursalim Ali Khan, et al. Design, synthesis, and cytotoxicity evaluation of 1,2,3-triazole-linked β-carboline-benzimidazole hybrids as tubulin polymerization inhibitors. New J. Chem., 2025,49, 17716-17729.