Tubulin-IN-61
Tubulin-IN-61 is a tubulin polymerization inhibitor with an IC50 of ≤7.63 μM. Tubulin-IN-61 induces early apoptosis and triggers significant G2/M phase arrest. Tubulin-IN-61 elevates intracellular ROS levels. Tubulin-IN-61 shows high activity against MCF-7 cells with an IC50 of 5.61 μM. Tubulin-IN-61 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C34H27N7O2S
- Molecular Weight:597.69
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Tubulin-IN-61 (compound 14d) shows potent cytotoxic activity on MCF-7, MDA-MB-231, HepG2, and A549 cancer cell lines with IC50 values of 5.61 μM, 18.86 μM, 21.78 μM, and 15.34 μM, respectively. Tubulin-IN-61 has high selectivity toward malignant over normal cells[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) effectively induce G2/M phase arrest in a dose-dependent manner[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) inhibits cell migration using a wound-healing assay on the MCF-7 breast cancer cell line[1].
Tubulin-IN-61 (3-12 μM; 48 hours; MCF-7) induces apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7
-
Concentration:3, 6, 9, 12 μM
-
Incubation Time:48 hours
-
Result:Induced G2/M phase arrest.
-
Cell Line:MCF-7
-
Concentration:3, 6, 12 μM
-
Incubation Time:48 hours
-
Result:Inhibited cell migration.
Displayed a marked reduction in wound closure compared to the untreated control group.
-
Cell Line:MCF-7
-
Concentration:3, 5, 12 μM
-
Incubation Time:48 h
-
Result:Apoptosis assays confirmed classical hallmarks of programmed cell death, including apoptotic body formation, nuclear condensation and fragmentation, membrane blebbing, and horseshoe-shaped nuclei, alongside elevated intracellular ROS levels.
Chemical Information
-
Molecular Weight 597.69
-
Formula C34H27N7O2S
-
SMILES
COC1=CC(C2=NC3=C(C=CC=C3)N2CC4=CN(N=N4)CC5=CC6=C(C(C7=CC=CS7)=N5)NC8=CC=CC=C86)=CC=C1OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin-IN-61 Related Classifications
HY-179160 Related Classifications
Powered by Bioz