1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Tubulin inhibitor 17

Tubulin inhibitor 17 

Cat. No.: HY-144748
Handling Instructions

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC50 of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis.

For research use only. We do not sell to patients.

Tubulin inhibitor 17 Chemical Structure

Tubulin inhibitor 17 Chemical Structure

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Description

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC50 of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis[1].

IC50 & Target

IC50: 12.38 µM (tubulin polymerization)[1]

In Vitro

Tubulin inhibitor 17 (Compound 3b) (0-10 µM, 0-72 h) displays antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells[1].
Tubulin inhibitor 17 (0-2.5 µM) inhibits tubulin polymerization in a concentration-dependent manner[1].
Tubulin inhibitor 17 (0-1 µM, 12 h) induces the collapse of the microtubule networks in a dose-dependent manner[1].
Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase and inhibits cell migration in HepG-2 cells[1].
Tubulin inhibitor 17 (0-5 μM, 48 h) induces HepG-2 cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: B16-F10, HepG-2, Hela and MCF-7
Concentration: 0, 0.5, 2.5, 5.0, 7.5 and 10 µM
Incubation Time: 48 h for IC50 measurement, 0-72 h for cell viability
Result: Displayed antiproliferative activities with IC50 values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 µM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a time- and concentration- dependent manner.

Cell Cycle Analysis[1]

Cell Line: HepG-2
Concentration: 0.5, 1.0 and 5.0 μM
Incubation Time: 24 h
Result: Dose-dependently induced cell cycle arrest at G2/M phase.

Apoptosis Analysis[1]

Cell Line: HepG-2
Concentration: 0.5, 1.0 and 5.0 μM
Incubation Time: 48 h
Result: The total proportion of apoptotic cells were increased significantly compared with the control.
Molecular Weight

264.32

Formula

C17H16N2O

SMILES

COC1=CC=C(C=C1)N(C2=CC=CC3=NC=CC=C23)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
Tubulin inhibitor 17
Cat. No.:
HY-144748
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