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Cat. No.: HY-144748

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Tubulin inhibitor 17

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC₅₀ of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2839151-13-0
Formula: C₁₇H₁₆N₂O
Molecular Weight:264.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Tubulin inhibitor 17 Chemical Structure

CAS No.: 2839151-13-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC₅₀ of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis^[1].

IC₅₀ & Target

IC₅₀: 12.38 µM (tubulin polymerization)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	0.563 μM Compound: 3b	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HeLa	IC₅₀	2.047 μM Compound: 3b	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HepG2	IC₅₀	0.261 μM Compound: 3b	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
MCF7	IC₅₀	0.609 μM Compound: 3b	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]

In Vitro

Tubulin inhibitor 17 (Compound 3b) (0-10 µM, 0-72 h) displays antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells^[1].
Tubulin inhibitor 17 (0-2.5 µM) inhibits tubulin polymerization in a concentration-dependent manner^[1].
Tubulin inhibitor 17 (0-1 µM, 12 h) induces the collapse of the microtubule networks in a dose-dependent manner^[1].
Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase and inhibits cell migration in HepG-2 cells^[1].
Tubulin inhibitor 17 (0-5 μM, 48 h) induces HepG-2 cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

B16-F10, HepG-2, Hela and MCF-7
Concentration:

0, 0.5, 2.5, 5.0, 7.5 and 10 µM
Incubation Time:

48 h for IC₅₀ measurement, 0-72 h for cell viability
Result:

Displayed antiproliferative activities with IC₅₀ values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 µM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a time- and concentration- dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

HepG-2
Concentration:

0.5, 1.0 and 5.0 μM
Incubation Time:

24 h
Result:

Dose-dependently induced cell cycle arrest at G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

HepG-2
Concentration:

0.5, 1.0 and 5.0 μM
Incubation Time:

48 h
Result:

The total proportion of apoptotic cells were increased significantly compared with the control.

Chemical Information

CAS No. 2839151-13-0
Molecular Weight 264.32
Formula C₁₇H₁₆N₂O
SMILES

COC1=CC=C(C=C1)N(C2=CC=CC3=NC=CC=C23)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ren Y, et al. Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities. Bioorg Med Chem. 2021 Sep 15;46:116376. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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