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Cat. No.: HY-146310

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Tubulin polymerization-IN-15

Tubulin polymerization-IN-15 (compound 4) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-15 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2055517-66-1
Formula: C₁₈H₁₇N₃O₄
Molecular Weight:339.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tubulin polymerization-IN-15 Chemical Structure

CAS No.: 2055517-66-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin polymerization-IN-15 (compound 4) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-15 has the potential for the research of cancer diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.1 μM Compound: 4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
HeLa	IC₅₀	11.4 μM Compound: 4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
SGC-7901	IC₅₀	0.87 μM Compound: 4	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]

Chemical Information

CAS No. 2055517-66-1
Molecular Weight 339.35
Formula C₁₈H₁₇N₃O₄
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OC)C2=NN(N=C2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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