2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-33

Tubulin polymerization-IN-33 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, exhibits high antiproliferative activity against the NCI panel.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-33 Chemical Structure

Tubulin polymerization-IN-33 Chemical Structure

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Tubulin polymerization-IN-33 Related Antibodies

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Description

Tubulin polymerization-IN-33 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, exhibits high antiproliferative activity against the NCI panel[1].

IC50 & Target

[1,2]oxazoloisoindoles tubulin polymerization[1]
In Vitro

Tubulin polymerization-IN-33 (compound 15K) (10 nM-100 μM; 72 h) has antiproliferative activity against 9 NCI subpanels (leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, breast) with GI50s ranging from 0.03 μM to 17.7 μM, and a mean graph_mid point (MG_MID) values of 0.49 μM[1].
Tubulin polymerization-IN-33 (0.15-10 μM; 72 h) shows potent growth inhibitory effects on different lymphoma lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-33 Related Antibodies

Cell Viability Assay[1]

Cell Line: Marginal zone lymphoma, mantle cell lymphoma, activated B-cell like diffuse large B cell lymphoma, germinal center B-cell-like diffuse large B cell lymphoma cells
Concentration: 0.15-10 μM
Incubation Time: 72 h
Result: Inhibited different lymphomas, with IC50s of 1.6 μM (Marginal zone lymphoma); 1.4 μM (mantle cell lymphoma); 1.7 μM (activated B-cell like diffuse large B cell lymphoma); 1.8 μM (germinal center B-cell-like diffuse large B cell lymphoma), respectively.
Molecular Weight

476.52

Formula

C27H28N2O6
SMILES

OCC1=NOC2=C1CCC3=C(C4=CC(OC)=C(OC)C(OC)=C4)N(CC5=CC=C(OC)C=C5)C=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-33Microtubule/TubulinMarginal zone lymphomaMZLmantle cell lymphomaMCLactivated B-cell like diffuse large B cell lymphomaABC-DLBCLgerminal center B-cell-like diffuse large B cell lymphomaGCBDLBCLoxazoloisoindoles tubulin polymerizationInhibitorinhibitorinhibit

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