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Cat. No.: HY-151982

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Tubulin polymerization-IN-39

Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC₅₀: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₁N₅O₅
Molecular Weight:423.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Tubulin polymerization-IN-39 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Tubulin polymerization-IN-39 (compound 4k) shows antiproliferative activity toward HeLa, HCT116, A549, and T47D, with the IC₅₀ values of 0.31, 1.28, 3.99 and 10.32 μM, respectively^[1].
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) increases percentages of HeLa cells at the G2/M phase^[1].
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) induces HeLa cells apoptosis by increasing cleaved PARP^[1].
Tubulin polymerization-IN-39 (0.2-0.8 μM, 24 h) inhibits the migration and the tube formation of HUVEC^[1].
Tubulin polymerization-IN-39 (10 μM) inhibits tubulin polymerization by 78%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HeLa cells
Concentration:

0.15, 0.3, 0.6 μM
Incubation Time:

24 h
Result:

Increased cyclin B1 protein level and cleaved PARP.
Decreased p-cdc2 (the inactive form of cdc2).

Cell Migration Assay ^[1]

Cell Line:

HUVEC
Concentration:

0.2, 0.4, 0.8 μM
Incubation Time:

24 h
Result:

Dose-dependently inhibited HUVEC migration.
Prevented HUVEC motility and migration (wound healing assay).

Chemical Information

Molecular Weight 423.42
Formula C₂₁H₂₁N₅O₅
SMILES

COC1=CC=C(C=C1O)C2=CC=NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NN23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors. Eur J Med Chem. 2022 Dec 15;244:114864. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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