Tubulin polymerization-IN-39 

Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC₅₀: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation^[1].

Tubulin polymerization-IN-39 (compound 4k) shows antiproliferative activity toward HeLa, HCT116, A549, and T47D, with the IC₅₀ values of 0.31, 1.28, 3.99 and 10.32 μM, respectively^[1].
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) increases percentages of HeLa cells at the G2/M phase^[1].
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) induces HeLa cells apoptosis by increasing cleaved PARP^[1].
Tubulin polymerization-IN-39 (0.2-0.8 μM, 24 h) inhibits the migration and the tube formation of HUVEC^[1].
Tubulin polymerization-IN-39 (10 μM) inhibits tubulin polymerization by 78%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

423.42

C₂₁H₂₁N₅O₅

COC1=CC=C(C=C1O)C2=CC=NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NN23

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen L, et al. Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors. Eur J Med Chem. 2022 Dec 15;244:114864.  [Content Brief]