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United States

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Cat. No.: HY-149594

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CL-Pa

CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis.

For research use only. We do not sell to patients.

Formula: C₃₈H₄₈N₂O₁₀
Molecular Weight:692.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CL-Pa Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis^[1].

Chemical Information

Molecular Weight 692.80
Formula C₃₈H₄₈N₂O₁₀
SMILES

O=C(OC)/C=C/C1=C(OCC2=CC=C(NC(CCNC(C(O)C(C)(C)CO)=O)=O)C=C2)C=C(C3(OC)C4([C@@H](C5)C[C@H]6C[C@@H]5C[C@@H]4C6)OO3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Nephrotoxicity Study
This protocol assesses nephrotoxicity by combining functional kidney injury readouts, urinary/tissue injury biomarkers, and renal histopathology. Serum creatinine and BUN reflect impaired kidney function, while KIM-1, NGAL, clusterin, osteopontin, IL-18, cystatin C, nephrin, Oat5, urinary protein, glucose, and alkaline phosphatase have been used to detect tubular injury in cisplatin-, gentamicin-, and acetaminophen-induced nephrotoxicity models.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yurong Feng, et al. Vanin-1-Activated Chemiluminescent Probe: Help to Early Diagnosis of Acute Kidney Injury with High Signal-to-Noise Ratio through Urinalysis. Anal Chem. 2023 Oct 3;95(39):14754-14761. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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