(S)-Baclofen
(S)-Baclofen is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values of 1.77 μM for GABAB and 1564 μM for GABAA. (S)-Baclofen can be used in research on muscle disorders such as spasticity.
For research use only. We do not sell to patients.
- Purity : 99.94%
- CAS No.: 66514-99-6
- Formula: C10H12ClNO2
- Molecular Weight:213.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 66514-99-6
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Appearance Solid
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Molecular Weight 213.66
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Formula C10H12ClNO2
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Color White to off-white
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SMILES
O=C(C[C@@H](C1=CC=C(C=C1)Cl)CN)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Froestl W, et al. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995;38(17):3297-3312. [Content Brief]
[2]. He Q, et al. Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules. 2020 Jan 8;25(2):250. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-Baclofen Related Classifications
HY-B0007B Related Classifications
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