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Cat. No.: HY-152194

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Tyrosinase-IN-10

Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates.

For research use only. We do not sell to patients.

CAS No.: 2873418-48-3
Formula: C₁₆H₁₂O₄
Molecular Weight:268.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Tyrosinase-IN-10 Chemical Structure

CAS No.: 2873418-48-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates^[1].

IC₅₀ & Target

IC50: 1.6 μM (human tyrosinase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MNT-1	CC₅₀	91 μM Compound: 23	Cytotoxicity against human MNT-1 cells Cytotoxicity against human MNT-1 cells	[PMID: 36462443]
MNT-1	IC₅₀	29 μM Compound: 23	Inhibition of melanogenesis in human MNT-1 cells incubated for 96 hrs Inhibition of melanogenesis in human MNT-1 cells incubated for 96 hrs	[PMID: 36462443]

In Vitro

Tyrosinase-IN-10 (Compound 23) (0-100 μM; 96 h) inhibits MNT-1 whole cells melanogenesis with an IC₅₀ of 29 μM and shows cytotoxicity with a CC₅₀ of 91 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MNT-1 cells
Concentration:

0-100 μM
Incubation Time:

96 h
Result:

Showed cytotoxicity with a CC₅₀ of 91 μM.

Chemical Information

CAS No. 2873418-48-3
Molecular Weight 268.26
Formula C₁₆H₁₂O₄
SMILES

O=C1C2=CC=CC(O)=C2C/C1=C\C3=C(C=C(C=C3)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Roulier B, et al. Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells. Eur J Med Chem. 2023 Jan 15;246:114972. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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