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Cat. No.: HY-136189

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UK-59811 hydrochloride

UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca²⁺ (Ca_V) channel Ca_VAb inhibitor with an IC₅₀ of 194 nM.

For research use only. We do not sell to patients.

CAS No.: 2250025-89-7
Formula: C₂₂H₃₀BrClN₂O₅
Molecular Weight:517.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

UK-59811 hydrochloride Chemical Structure

CAS No.: 2250025-89-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca²⁺ (Ca_V) channel Ca_VAb inhibitor with an IC₅₀ of 194 nM^[1].

IC₅₀ & Target

IC50: 194 nM (Ca_VAb)^[1]

All Calcium Channel Isoforms :

Chemical Information

CAS No. 2250025-89-7
Molecular Weight 517.84
Formula C₂₂H₃₀BrClN₂O₅
SMILES

O=C(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)OCC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin Tang, et al. Structural basis for inhibition of a voltage-gated Ca²⁺ channel by Ca²⁺ antagonist drugs. Nature. 2016 Sep 1;537(7618):117-121. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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UK-59811 hydrochloride

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

UK-59811 hydrochloride Related Classifications

HY-136189 Related Classifications