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Hyaluronic acid

(Synonyms: Hyaluronan; Hyaluronate)
19 Cited Publications
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Based on 19 publication(s) in Google Scholar

Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer.

For research use only. We do not sell to patients.

  • CAS No.: 9004-61-9
  • Formula: (C14H21NO11)n
  • Molecular Weight:379.32 (monomer)
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Hyaluronic acid Chemical Structure
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Hyaluronic acid Chemical Structure
    Hyaluronic acid Chemical Structure
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
  • Experimental Validation Results for Hyaluronic acid
CAS No.: 9004-61-9
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IFHistological Imaging/StainingIHCApoptosis AnalysisIn Vivo Efficacy Study
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  • Apoptosis Analysis
  • In Vivo Efficacy Study

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  • Hyaluronic acid Chemical Structure
    Hyaluronic acid Chemical Structure
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    Hyaluronic acid purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 Oct;42(44):3221-3235. [Abstract]

    Customer Validation
     4T1 cells mixed with exogenous Hyaluronic acid (HA, 500 μg) were subcutaneously inoculated into BALB/c mice, the mice were sacrificed on the eighth day after tumor graft. Representative immunofluorescent images of HA (green) and Hoechst33342 (blue) in tumors (left, scale bar, 100 μm), and statistic result of the MFI of HA (right), n = 4. P values were calculated by two-tailed unpaired t tests. E-F, The MSCs supernatant react with increasing dose of DOX. The results showed that exogenous HA was effectively converted into increased intratumoral HA content when assayed on the eighth day after tumor implantation.

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    Hyaluronic acid purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996. [Abstract]

    Customer Validation
     Photomicrograph of the visual cortex in section following hyaluronic acid injection and caffeine treatment. C (control group) revealed a normal neuronal cells distribution pattern with distinct nuclei; HA (Hyaluronic acid group; 25 μL/kg; single injection at the unilateral corneoscleral limbus) revealed pyknotic and scanty distribution of neuronal cells. PHA (intervention group) revealed histological alteration when compared to control group. CAF (caffeine group; 20 mg/kg; i.p.; once daily for 7 days) revealed scantily distribution of normal neuronal cells. Stained with H&E, (Scale bar = 51 μm).

  • 1/16

    Hyaluronic acid purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996. [Abstract]

    Customer Validation
     Photomicrograph showing TNF-α in a rat glaucomatous visual cortex. C represents the control group; HA (Hyaluronic acid; 25 μL/kg; single injection at the unilateral corneoscleral limbus) represent the hyaluronic acid group; PHA represents the intervention group; CAF represent the caffeine group. The expressions of TNF-α, and the damaged cells were characterized by a deep brown precipitates, round and shrunken morphology. (Scale bar = 51 μm).

  • 1/16

    Hyaluronic acid purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996. [Abstract]

    Customer Validation
     Effect of Caffeine on the tumour necrosis factor in the LGB and visual cortex of HA (25 μL/kg; single injection at the unilateral corneoscleral limbus)-induced rat. A): Tunel assay immunoreactivity in the primary visual cortex. B): Tunel assay immunoreactivity in the Lateral geniculate nucleus (LGN). Data represented as mean ± S.E.M. (n = 4). C = Control, HA= Hyaluronic acid, PHA = Post treatment group, CAF = Caffeine.

  • 1/16

    Hyaluronic acid purchased from MedChemExpress. Usage Cited in: J Chem Neuroanat. 2021 Nov:117:101996. [Abstract]

    Customer Validation
     Tonopen measurements of IOP in rats with hyaluronic acid injection and caffeine treatment. The elevated IOP was observed in rats injected with hyaluronic acid compared to the control and caffeine group. The distinction between the control, CAF and HA (Hyaluronic acid group; 25 μL/kg; single injection at the unilateral corneoscleral limbus) group was statistically significant after 8 days of HA injection. Control (C); hyaluronic acid (HA); Post hyaluronic acid (PHA); Caffeine (CAF); Intraocular pressure (IOP) *P < 0.05 (P value = 0.0001).

  • Hyaluronic acid