NFIC - nuclear factor I C Gene

Also Known as CTF; NFI; CTF5; NF-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4782

About NFIC

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,359,630-3,469,217 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 22.7), ovary (RPKM 18.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NFIC Products (5)

mRNA	Protein	Name
NM_001245002.2	NP_001231931.1	nuclear factor 1 C-type isoform 1
NM_001245004.2	NP_001231933.1	nuclear factor 1 C-type isoform 3
NM_001245005.2	NP_001231934.1	nuclear factor 1 C-type isoform 4
NM_005597.4	NP_005588.2	nuclear factor 1 C-type isoform 5
NM_205843.3	NP_995315.1	nuclear factor 1 C-type isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1524678	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1524678	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1524678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24145797	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	1524678	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1524678	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19706729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFIC Protein Structure

NfI_DNAbd_pre-N

MH1

CTF_NFI

0
100
200
300
400
508 a.a.

Protein Preferred Names	Protein Names
nuclear factor 1 C-type	CCAAT-box-binding transcription factor

NFIC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	Affinity Chrom	35140242
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	Anti Tag CoIP	25258084
Intra	NFIC	P08651	NFIB	Homo sapiens	O00712	BioID	35140242
Intra	NFIC	P08651	PARP1	Homo sapiens	P09874	Anti Bait CoIP	24145797

Cross: Cross-species interaction Intra: Intraspecies interaction

NFIC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85444	NFIC Antibody (YA5136)	WB	Human, Mouse, Rat, Bovine, Chicken, Pig
HY-P85511	NFIC Antibody (YA5203)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Mechanical Ectropion
Marshall-Smith Syndrome	MRSHSS Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome Mss
Neurofibrosarcoma	Neurosarcoma Malignant Peripheral Nerve Sheath Tumor
Plexiform Neurofibroma	Neurofibroma Plexiform Neurofibroma, Plexiform
Optic Nerve Glioma	Glioma Of The Optic Nerve
Blount'S Disease	Blount Disease Tibia Vara Osteochondrosis Deformans Tibiae Osteochondrosis Deformans Tibiae, Familial Infantile Type Familial Infantile Type Osteochondrosis Deformans Tibiae Blount-Barber Syndrome Erlacher-Blount Syndrome Infantile Tibia Vara Tibia Vara Blount Blount Disease, Infantile
Scrotum Neoplasm	Malignant Tumour Of Scrotum Malignant Scrotal Neoplasm Malignant Tumor Of Scrotum Neoplasm Of Scrotum Scrotal Ca Scrotal Tumor Scrotum Cancer Cancer Of Scrotum Malignant Neoplasm Of Scrotum Scrotal Cancer Malignant Scrotal Tumour Malignant Neoplasm Of Skin Of Scrotum Primary Malignant Neoplasm Of Scrotum
Optic Nerve Neoplasm	Optic Nerve Neoplasms Neoplasm Of Optic Nerve Tumor Of Second Cranial Nerve Tumour Of Optic Nerve
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Elephantiasis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09251	NFIC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21390	Nfic Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27909	Nfic Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NFIC	VGNC	VGNC:75336
Rattus norvegicus	NFIC	RGD	RGD:62016
Felis catus	NFIC	VGNC	VGNC:80638
Canis familiaris	NFIC	VGNC	VGNC:43777
Bos taurus	NFIC	VGNC	VGNC:32040
Mus musculus	NFIC	MGD	MGI:109591
Others	NFIC	NCBI