Anticancer agent-365
Anticancer agent-365 is a pyrimidine-benzothiazole hybrid derivative that exhibits selective antiproliferative activity against A549 and MCF-7 tumor cells. Anticancer agent-365 is predicted to bind within the ATP-binding pocket of the VEGFR-2 kinase domain. Anticancer agent-365 possesses DNA intercalating binding ability, DNA oxidative damage protective activity, and antioxidant free radical scavenging activity. Anticancer agent-365 can be used for research on lung cancer and breast cancer.
For research use only. We do not sell to patients.
- Formula: C22H18FN7O4S2
- Molecular Weight:527.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6.18 μM
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Antiproliferative activity against human lung carcinoma A549 cells assessed as reduction in cell viability by MTT assay.
Antiproliferative activity against human lung carcinoma A549 cells assessed as reduction in cell viability by MTT assay.
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42641238 |
| MCF7 | IC50 |
9.30 μM
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Antiproliferative activity against human breast adenocarcinoma MCF-7 cells assessed as reduction in cell viability by MTT assay.
Antiproliferative activity against human breast adenocarcinoma MCF-7 cells assessed as reduction in cell viability by MTT assay.
|
42641238 |
In Vitro
Anticancer agent-365 (K12) exhibits potent antiproliferative activity against A549 (IC50 = 6.18 μM) and MCF-7 (IC50 = 9.30 μM) cancer cell lines, with selectivity over normal HEK-293 cells[1].
Anticancer agent-365 (15.625-1000 μg/mL) exhibits moderate antioxidant activity in the DPPH assay, with an IC50 > 1000 μg/mL[1].
Anticancer agent-365 exhibits strong DNA binding affinity with HS-DNA and CT-DNA through an intercalative binding mode; it also effectively protects pBR322 plasmid DNA from Fenton reagent-induced oxidative damage[1].
Anticancer agent-365 is predicted to exhibit good binding affinity for the VEGFR-2 kinase domain, with an XP GlideScore of -9.577 kcal/mol; moreover, it forms a stable and rigid complex with the VEGFR-2 kinase domain during a 501 ns MD simulation, with a binding free energy (ΔGbind) of -63.29 kcal/mol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 527.55
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Formula C22H18FN7O4S2
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SMILES
O=C(OC)C1=CC(S2)=C(C=C1)N=C2NC(C(C=C3)=C(F)C=C3NC(CSC4=NC(N)=CC(N)=N4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent-365 Related Classifications
HY-189298 Related Classifications
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