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Volixibat (Synonyms: SHP626; LUM002)

Cat. No.: HY-101190
Handling Instructions

Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH).

For research use only. We do not sell to patients.

Volixibat Chemical Structure

Volixibat Chemical Structure

CAS No. : 1025216-57-2

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Description

Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH)[1][2].

In Vivo

Volixibat (SHP626) (5-30 mg/kg; food intake; daily for 24 weeks) improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice[1].

Animal Model: Male Ldlr-/-.Leiden mice (high-fat diet, HFD)[1]
Dosage: 5, 15, or 30 mg/kg
Administration: Food intake; daily for 24 weeks
Result: Significantly increased the total amount of bile acid in feces. Significantly attenuated the HFD-induced increase in hepatocyte hypertrophy, hepatic triglyceride and cholesteryl ester levels, and mesenteric white adipose tissue deposition at the highest dose. Non-alcoholic fatty liver disease activity score (NAS) was significantly lower in volixibat-treated mice than in the HFD controls.
Molecular Weight

805.95

Formula

C₃₈H₅₁N₃O₁₂S₂

CAS No.

1025216-57-2

SMILES

O=C(N[[email protected]]1[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](COS(=O)(O)=O)O1)O)OCC2=CC=CC=C2)O)NC3=CC=CC([[email protected]](C4=CC(N(C)C)=CC=C45)[[email protected]@H](O)[[email protected]](CC)(CCCC)CS5(=O)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VolixibatSHP626LUM002SHP 626SHP-626LUM 002LUM-002Othershigh-fatdietnon-alcoholicsteatohepatitismetabolictransporterInhibitorinhibitorinhibit

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Volixibat
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