Wnt pathway inhibitor 4
Based on 1 Customer Validation
Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 663214-57-1
- Formula: C19H15BrN2O5
- Molecular Weight:431.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
23.3 nM
Compound: 16d
|
Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
Antiproliferative activity against human A375 cells after 72 hrs by MTS assay
|
[PMID: 30099258] |
| Huh-7 | CC50 |
>100 μM
Compound: GNF-Pf-3233
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
[PMID: 18579783] |
Chemical Information
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CAS No. 663214-57-1
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Appearance Solid
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Molecular Weight 431.24
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Formula C19H15BrN2O5
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Color White to off-white
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SMILES
N#CC1=C(N)OC2=C(C1C3=CC(Br)=C(C(OC)=C3)OC)C=C4OCOC4=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 16.67 mg/mL (38.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3189 mL | 11.5945 mL | 23.1889 mL | 57.9724 mL |
| 5 mM | 0.4638 mL | 2.3189 mL | 4.6378 mL | 11.5945 mL | |
| 10 mM | 0.2319 mL | 1.1594 mL | 2.3189 mL | 5.7972 mL | |
| 15 mM | 0.1546 mL | 0.7730 mL | 1.5459 mL | 3.8648 mL | |
| 20 mM | 0.1159 mL | 0.5797 mL | 1.1594 mL | 2.8986 mL | |
| 25 mM | 0.0928 mL | 0.4638 mL | 0.9276 mL | 2.3189 mL | |
| 30 mM | 0.0773 mL | 0.3865 mL | 0.7730 mL | 1.9324 mL |