YAP/TEAD-IN-2
Based on 1 Customer Validation
YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor. YAP/TEAD-IN-2 inhibits the luciferase activity driven by YAP/TEAD in 293T cells. YAP/TEAD-IN-2 exhibits strong anti-proliferative activity against human pleural mesothelioma NCI-H226 cells. YAP/TEAD-IN-2 can be used for the study of diseases associated with Hippo pathway dysregulation, particularly cancers.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2957895-40-6
- Formula: C21H20N6O3
- Molecular Weight:404.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
All YAP Isoforms
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Biological Activity
YAP/TEAD-IN-2 (2.5 μM, 72 h) significantly reduces luciferase activity in 293T cells transfected with 3xSDYAP-luci and Renilla plasmids[1].
YAP/TEAD-IN-2 (0.15 nM-333.33 nM, 3 days) inhibits the proliferation of human pleural mesothelioma NCI-H226 cells[1].
YAP/TEAD-IN-2 (48 h) inhibits YAP-TEAD-mediated reporter gene activity in 293T cells transfected with pGL3B-8xGTiiC-nLuc-CMV-fLuc plasmid[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2957895-40-6
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Appearance Solid
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Molecular Weight 404.42
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Formula C21H20N6O3
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Color White to off-white
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SMILES
O=C(C1=NN=C(C(C=NN23)=C3NC(C4=CC=C(C5CCCCC5)C=C4)=CC2=O)O1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)