YAP/TEAD-IN-2 

YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor. YAP/TEAD-IN-2 inhibits the luciferase activity driven by YAP/TEAD in 293T cells. YAP/TEAD-IN-2 exhibits strong anti-proliferative activity against human pleural mesothelioma NCI-H226 cells. YAP/TEAD-IN-2 can be used for the study of diseases associated with Hippo pathway dysregulation, particularly cancers^[1].

YAP/TEAD-IN-2 (2.5 μM, 72 h) significantly reduces luciferase activity in 293T cells transfected with 3xSDYAP-luci and Renilla plasmids^[1].
YAP/TEAD-IN-2 (0.15 nM-333.33 nM, 3 days) inhibits the proliferation of human pleural mesothelioma NCI-H226 cells^[1].
YAP/TEAD-IN-2 (48 h) inhibits YAP-TEAD-mediated reporter gene activity in 293T cells transfected with pGL3B-8xGTiiC-nLuc-CMV-fLuc plasmid^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

404.42

C₂₁H₂₀N₆O₃

2957895-40-6

Solid

White to off-white

O=C(C1=NN=C(C(C=NN23)=C3NC(C4=CC=C(C5CCCCC5)C=C4)=CC2=O)O1)N

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Liang Apeng, et al. Polycyclic Compounds and Their Uses. Patent No. CN 116425757 A. National Intellectual Property Administration of the People's Republic of China. Publication Date: July 14, 2023.