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Cat. No.: HY-151141

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α-Glucosidase-IN-17

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active α-glucosidase inhibitor with an IC₅₀ of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity.

For research use only. We do not sell to patients.

CAS No.: 2820424-84-6
Formula: C₃₀H₂₇NO₂S
Molecular Weight:465.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

α-Glucosidase-IN-17 Chemical Structure

CAS No.: 2820424-84-6

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active α-glucosidase inhibitor with an IC₅₀ of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity^[1].

IC₅₀ & Target

IC₅₀: 3.79 μM (α-glucosidase)^[1]

In Vivo

α-Glucosidase-IN-17 (Compound 12B) (10 and 20 mg/kg; p.o.; b.w. for 4 weeks) shows antidiabetic activity in Streptozocin (HY-13753)-induced diabetic rats^[1].
α-Glucosidase-IN-17 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats^[1].
α-Glucosidase-IN-17 (2000mg/kg; p.o.; b.w. for 2 weeks) demonstrates no mortality in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar albino rats (170–200 g), Streptozotocin-induced diabetes model^[1]
Dosage:

10 and 20 mg/kg
Administration:

Oral administration, b.w. for 4 weeks
Result:

Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers.

Chemical Information

CAS No. 2820424-84-6
Molecular Weight 465.61
Formula C₃₀H₂₇NO₂S
SMILES

COC1=CC(C2CC(C3=CC=C(C=C3)C)=NC4=C(S2)C=CC=C4)=CC=C1OCC5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

January 25, 2022.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mehmood R, et al. Synthesis of Novel 2, 3-Dihydro-1, 5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega, 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

α-Glucosidase-IN-17

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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α-Glucosidase-IN-17

Publications Citing Use of MedChemExpress (MCE) α-Glucosidase-IN-17

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

α-Glucosidase-IN-17 Related Classifications

HY-151141 Related Classifications