2-Methoxypyridine-3-boronic acid
Based on 1 Customer Validation
2-Methoxypyridine-3-boronic acid is a pyridine boronic acid compound and also borylation reagent used in Suzuki cross-coupling reactions.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 163105-90-6
- Formula: C6H8BNO3
- Molecular Weight:152.95
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-75129
Pyridin-3-ylboronic acid -
HY-32957
2-Methoxypyridine-5-boronic acid -
HY-W002908
2-Methoxycarbonylphenylboronic acid -
HY-32959
N-Boc-2-pyrroleboronic acid -
HY-Y0395
3-Carboxyphenylboronic acid -
HY-77642
4-(Methylsulfonyl)phenylboronic acid -
HY-50807
4-Nitrophenylboronic acid -
HY-50284
N-Boc-indole-2-boronic acid -
HY-W002463
3-Chlorophenyl boronic acid -
HY-W003977
Methyl 4-boronobenzoate -
HY-34469
2-Cyanophenylboronic acid -
HY-W000902
2,6-Dimethoxypyridine-3-boronic acid
Biological Activity
Description
In Vitro
2-Methoxypyridine-3-boronic acid serves as a boronic acid building block in Suzuki-Miyaura cross-coupling reactions for the synthesis of pyridine-derived Bedaquiline (HY-14881) analogs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 163105-90-6
-
Appearance Solid
-
Molecular Weight 152.95
-
Formula C6H8BNO3
-
Color White to off-white
-
SMILES
COC1=NC=CC=C1B(O)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (653.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (32.69 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (32.69 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (288 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.5381 mL | 32.6904 mL | 65.3808 mL | 163.4521 mL |
| 5 mM | 1.3076 mL | 6.5381 mL | 13.0762 mL | 32.6904 mL | |
| 10 mM | 0.6538 mL | 3.2690 mL | 6.5381 mL | 16.3452 mL | |
| 15 mM | 0.4359 mL | 2.1794 mL | 4.3587 mL | 10.8968 mL | |
| 20 mM | 0.3269 mL | 1.6345 mL | 3.2690 mL | 8.1726 mL | |
| 25 mM | 0.2615 mL | 1.3076 mL | 2.6152 mL | 6.5381 mL | |
| 30 mM | 0.2179 mL | 1.0897 mL | 2.1794 mL | 5.4484 mL | |
| 40 mM | 0.1635 mL | 0.8173 mL | 1.6345 mL | 4.0863 mL | |
| 50 mM | 0.1308 mL | 0.6538 mL | 1.3076 mL | 3.2690 mL | |
| 60 mM | 0.1090 mL | 0.5448 mL | 1.0897 mL | 2.7242 mL | |
| 80 mM | 0.0817 mL | 0.4086 mL | 0.8173 mL | 2.0432 mL | |
| 100 mM | 0.0654 mL | 0.3269 mL | 0.6538 mL | 1.6345 mL |
2-Methoxypyridine-3-boronic acid Related Classifications
HY-32956 Related Classifications
Powered by Bioz
Keywords
- 2-Methoxypyridine-3-boronic acid
- 163105-90-6
- Biochemical Assay Reagents
- pyridine-derived bedaquiline analogues
- Suzuki-Miyaura cross-coupling
- Suzuki cross-coupling reactions
- aryl/heteroaryl halide substrates
- CS/PVA@Pd
- vinyl bromide 4
- borylation reagent
- pyridineboronic acid
- enol acetate 5
- Inhibitor
- inhibitor
- inhibit