2-MSP-5-HA-VC-PAB-MMAE
Based on 1 Customer Validation
2-MSP-5-HA-VC-PAB-MMAE (Compound B-1) is a Drug-Linker Conjugates for ADC. 2-MSP-5-HA-VC-PAB-MMAE consists of the ADC Cytotoxin Monomethyl auristatin E (HY-15162) and a linker 2-MSP-5-HA-VC-PAB-OH (HY-177905). 2-MSP-5-HA-VC-PAB-MMAE can be used for synthesis of ADCs.
For research use only. We do not sell to patients.
- Purity: 98.59%
- CAS No.: 2878440-80-1
- Formula: C69H104N12O15S
- Molecular Weight:1373.70
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Monomethyl auristatin E is a synthetic derivative of sea hare toxin 10. It exerts an effective mitotic inhibition effect by inhibiting the polymerization of tubulin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2878440-80-1
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Appearance Solid
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Molecular Weight 1373.70
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Formula C69H104N12O15S
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Color White to off-white
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SMILES
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC#CC4=CN=C(S(C)(=O)=O)N=C4)=O)=O)=O)=O)=O)=O)=O)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (72.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7280 mL | 3.6398 mL | 7.2796 mL | 18.1990 mL |
| 5 mM | 0.1456 mL | 0.7280 mL | 1.4559 mL | 3.6398 mL | |
| 10 mM | 0.0728 mL | 0.3640 mL | 0.7280 mL | 1.8199 mL | |
| 15 mM | 0.0485 mL | 0.2427 mL | 0.4853 mL | 1.2133 mL | |
| 20 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9100 mL | |
| 25 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.7280 mL | |
| 30 mM | 0.0243 mL | 0.1213 mL | 0.2427 mL | 0.6066 mL | |
| 40 mM | 0.0182 mL | 0.0910 mL | 0.1820 mL | 0.4550 mL | |
| 50 mM | 0.0146 mL | 0.0728 mL | 0.1456 mL | 0.3640 mL | |
| 60 mM | 0.0121 mL | 0.0607 mL | 0.1213 mL | 0.3033 mL |
2-MSP-5-HA-VC-PAB-MMAE Related Classifications
HY-177880 Related Classifications
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