2′-β-C-Methyl isoguanosine
2′-β-C-Methyl isoguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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- No. CAS: 714249-83-9
- Fòrmula: C11H15N5O5
- Peso molecular:297.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
>100 μM
Compound: 25
|
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
Cytotoxicity against human CEM cells after 6 days by trypan blue exclusion assay
|
[PMID: 26819659] |
| Huh-7 | CC50 |
>10 μM
Compound: 25
|
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
Cytotoxicity against human HuH7 cells infected with HCV assessed as reduction in cellular rRNA level after 96 hrs by qRT-PCR analysis
|
[PMID: 26819659] |
| PBMC | CC50 |
>100 μM
Compound: 25
|
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay
|
[PMID: 26819659] |
| Vero | CC50 |
>100 μM
Compound: 25
|
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
Cytotoxicity against African green monkey Vero cells after 3 days by hemocytometry
|
[PMID: 26819659] |
Chemical Information
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No. CAS 714249-83-9
-
Peso molecular 297.27
-
Fòrmula C11H15N5O5
-
SMILES
OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C=NC3=C2NC(N=C3N)=O)O1
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Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)