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Cat. No.: HY-N20726

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20(R)-25-Methoxyprotopanaxadiol

Name: 20(R)-25-Methoxyprotopanaxadiol
Brand: MedChemExpress
SKU: HY-N20726
Availability: PreOrder

(Synonyms: 20(R)-25-OCH3-PPD)

20(R)-25-Methoxyprotopanaxadiol (20(R)-25-OCH3-PPD) is a dammarane-type triterpene sapogenin found in Panax ginseng berries. 20(R)-25-Methoxyprotopanaxadiol induces cytotoxicity in cancer cells. 20(R)-25-Methoxyprotopanaxadiol can be used for the research of lung cancer.

For research use only. We do not sell to patients.

CAS No.: 1050479-86-1
Formula: C₃₁H₅₆O₄
Molecular Weight:492.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

20(R)-25-Methoxyprotopanaxadiol Chemical Structure

CAS No.: 1050479-86-1

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	35.62 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21216145]
A549	IC₅₀	38.5 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30108895]
A549	IC₅₀	29.28 μM Compound: 3	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
BGC-823	IC₅₀	39.6 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 30108895]
BGC-823	IC₅₀	36 μM Compound: AD-1	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 30527868]
COLO 205	IC₅₀	14.2 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay	[PMID: 21216145]
DU-145	IC₅₀	11.83 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 21216145]
DU-145	IC₅₀	5.4 μM Compound: 25-OCH3-PPD	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27561718]
DU-145	IC₅₀	40.7 μM Compound: AD-1	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 30527868]
HCT-116	IC₅₀	44.2 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30108895]
HeLa	IC₅₀	22.5 μM Compound: 25-OCH3-PPD	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27561718]
HeLa	IC₅₀	29.36 μM Compound: 3	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
HepG2	IC₅₀	8.32 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21216145]
HepG2	IC₅₀	35.9 μM Compound: AD-1	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30527868]
HL-60	IC₅₀	8.48 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21216145]
LNCaP C4-2B	IC₅₀	37.5 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human C4-2B cells after 48 hrs by MTT assay Antiproliferative activity against human C4-2B cells after 48 hrs by MTT assay	[PMID: 30108895]
MCF7	IC₅₀	8.34 μM Compound: 20(S)-25-OCH3-PPD	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21216145]
MCF7	IC₅₀	36.9 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30108895]
MCF7	IC₅₀	44.59 μM Compound: 3	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
MCF7	IC₅₀	31.3 μM Compound: AD-1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30527868]
PC-3	IC₅₀	39.5 μM Compound: AD-1	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 30527868]
SGC-7901	IC₅₀	44.7 μM Compound: AD-1; 25-OCH3-PPD	Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay	[PMID: 30108895]
U-87MG ATCC	IC₅₀	19.51 μM Compound: 3	Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]

In Vitro

20(R)-25-Methoxyprotopanaxadiol (20-60 μM; 48 h) potently inhibits human lung cancer A549 cell viability with an IC₅₀ of 8.225 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human lung cancer A549 cells
Concentration:

20 μM, 60 μM
Incubation Time:

48 h
Result:

Showed dose-dependent cytotoxicity against A549 cells, causing nearly maximum mortality at 20 μM and reaching full maximum mortality at 60 μM.
Exhibited an IC₅₀ value of 8.225 μM.

Chemical Information

CAS No. 1050479-86-1
Molecular Weight 492.77
Formula C₃₁H₅₆O₄
SMILES

C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@]3([H])[C@](C)(O)CCCC(C)(C)OC)C)O)([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC1)C
Synonyms

20(R)-25-OCH3-PPD
Structure Classification
- Steroids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang S, et al. Crystallization-induced dynamic resolution R-epimer from 25-OCH3-PPD epimeric mixture. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Nov 15;1005:39-46. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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