20S Proteasome-IN-3

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20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM). 20S Proteasome-IN-3 shows anti-tumor proliferation activity.

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20S Proteasome-IN-3 Chemische Struktur

CAS. Nr. : 1803040-07-4

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM)^[1]^[2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity^[2].

IC₅₀ & Target

IC50: 1.64 μM (20S proteasome β5 subunit)^[1]

In Vitro

20S Proteasome-IN-3 (Compound 10b) (5.34-9.69 μM, 18-24 h) exhibits significant inhibition against A375, SW480, DU145, and HeLa cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	A375, SW480, DU145, and HeLa cell lines
Concentration:	5.34-9.69 μM
Incubation Time:	18-24 hours
Result:	Inhibited the proliferation of SW480, DU145, A375 and HeLa cells with the IC₅₀s of 5.34, 9.69, 5.66 and 7.03 μM, respectively.

Molekulargewicht

621.72

Formel

C₃₄H₄₃N₃O₈

CAS. Nr.

1803040-07-4

SMILES

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160. [Content Brief]

[2]. Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10(3):498-510. [Content Brief]