country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189256

Copy Link Print Information

20S Proteasome-IN-6

20S Proteasome-IN-6 is a species-selective inhibitor of the Mycobacterium tuberculosis 20S proteasome. 20S Proteasome-IN-6 penetrates the Mycobacterium tuberculosis bacilli, sensitizes the bacteria to nitrosative stress, and reduces the bacterial burden of live Mycobacterium tuberculosis within infected macrophages. 20S Proteasome-IN-6 can be used for tuberculosis research.

For research use only. We do not sell to patients.

Formula: C₂₉H₄₀N₆O₆
Molecular Weight:568.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

20S Proteasome-IN-6 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

20S Proteasome-IN-6 (inhibitor 2) is a potent inhibitor of the Mtb 20S proteasome, with a k_inact/K_i of 1781 M^-1 s^-1; it inhibits the β5 subunit of the human 20S proteasome with a k_inact/K_i of 17.24 M^-1 s^-1, exhibiting a species selectivity index of 103-fold^[1].
20S Proteasome-IN-6 (0.14‑33.33 μM) penetrates live Mycobacterium tuberculosis and inhibits proteasome activity, thereby effectively stabilizing Pup-Gfp fluorescence^[1].
20S Proteasome-IN-6 (33.3 μg/mL; co-incubated with DETA-NO) sensitizes wild-type Mycobacterium tuberculosis H37Rv to nitric oxide-induced nitrosative stress, thereby exerting bacteriostatic-bactericidal effects in the presence of a nitric oxide donor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

20S Proteasome-IN-6 (inhibitor 2) (50 μM with/without 0.03 μg/mL Pretomanid (HY-10844); 5-day incubation) reduces mycobacterial colony-forming unit burden in Mycobacterium tuberculosis H37Rv-infected mouse macrophages and human macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 568.66
Formula C₂₉H₄₀N₆O₆
SMILES

CC[C@H]([C@@H](C(OC)=O)NC(NCC(N[C@H]1CCCCNC(/C=C/[C@@H](NC1=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gu X L, et al. Substrate Mimicry by Inhibitors of the Mycobacterium tuberculosis 20S Proteasome and Their Activity against Mycobacteria In Vitro and in Macrophages. ACS Chemical Biology, 2026.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote