(2R,3R,4R)-2-Methylpiperidine-3,4-diol
(2R,3R,4R)-2-Methylpiperidine-3,4-diol is a six-membered ring iminosugar analog. Fagomine (HY-13005), an analog of (2R,3R,4R)-2-hydroxymethylpiperidine-3,4-diol, exhibits weak inhibitory activity against hepatic glycogen phosphorylase, while its isomer Isofagomine (HY-14829) possesses potent inhibitory activity. (2R,3R,4R)-2-Methylpiperidine-3,4-diol can be used in studies related to type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 197449-09-5
- Formula: C6H13NO2
- Molecular Weight:131.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(2R,3R,4R)-2-hydroxymethylpiperidine-3,4-diol (compound 53) is the parent scaffold of Fagomine (HY-13005), a known glycosidase inhibitor. Fagomine exhibits weak inhibitory activity against hepatic glycogen phosphorylase (IC50 = 200 μM), while its stereoisomer Isofagomine (HY-14829) displays potent inhibitory activity (IC50 = 0.7 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 197449-09-5
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Molecular Weight 131.18
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Formula C6H13NO2
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SMILES
O[C@H]1[C@H](O)CCN[C@@H]1C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2R,3R,4R)-2-Methylpiperidine-3,4-diol Related Classifications
HY-N20714 Related Classifications
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