3-Deazahomoneplanocin A
3-Deazahomoneplanocin A is an S-adenosylhomocysteine (AdoHcy) hydrolase inhibitor with an IC50 of 3.76 μM. 3-Deazahomoneplanocin A exhibits antiviral activity against VSV. It also shows anticancer activity against lung cancer, colon cancer, breast cancer, liver cancer and gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 161128-65-0
- Formula: C13H16N4O3
- Molecular Weight:276.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
76.48 μM
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Antiproliferative activity against human lung cancer A549 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human lung cancer A549 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
|
26010585 |
| HCT-116 | IC50 |
17.94 μM
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Antiproliferative activity against human colon cancer HCT116 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human colon cancer HCT116 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
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26010585 |
| MDA-MB-231 | IC50 |
8.01 μM
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Antiproliferative activity against human breast cancer MDA-MB-231 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human breast cancer MDA-MB-231 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
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26010585 |
| PC-3 | IC50 |
>100 μM
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Antiproliferative activity against human prostate cancer PC3 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human prostate cancer PC3 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
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26010585 |
| SK-HEP1 | IC50 |
28.89 μM
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Antiproliferative activity against human liver cancer SK-hep-1 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human liver cancer SK-hep-1 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
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26010585 |
| SNU-638 | IC50 |
28.16 μM
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Antiproliferative activity against human stomach cancer SNU-638 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
Antiproliferative activity against human stomach cancer SNU-638 cells assessed as reduction in cell proliferation incubated for 72 hrs by sulforhodamine B (SRB) assay.
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26010585 |
| Vero | IC50 |
3.9 μg/mL
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Inhibition of vesicular stomatitis virus (VSV)-induced cytopathogenicity in Vero cells.
Inhibition of vesicular stomatitis virus (VSV)-induced cytopathogenicity in Vero cells.
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8691433 |
3-Deazahomoneplanocin A (Various concentrations; 10 min preincubation, 20 min reaction) inhibits recombinant human placental AdoHcy hydrolase with an IC50 of 0.44 μM[1].
3-Deazahomoneplanocin A (Various concentrations; 72 h) exhibits potent anticancer activity in human lung (A549), colon (HCT116), breast (MDA-MB-231), liver (SK-hep-1), and stomach (SNU-638) cancer cell lines, with IC50 values ranging from 0.26 μM to 9.39 μM, and shows moderate activity against human prostate (PC3) cancer cell line (IC50 = 9.39 μM)[1].
3-Deazahomoneplanocin A (Compound 4) (up to 500 μg/mL) inhibits vesicular stomatitis virus in Vero cells with an IC50 of 3.9 μg/mL and is non-cytotoxic to Vero cells at concentrations up to 500 μg/mL, while showing no activity against parainfluenza virus in the same system[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human lung cancer (A549), human colon cancer (HCT116), human breast cancer (MDA-MB-231), human prostate cancer (PC3), human liver cancer (SK-hep-1), human stomach cancer (SNU-638)
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Concentration:Various concentrations
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Incubation Time:72 h
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Result:Inhibited proliferation of A549 cells with an IC50 value of 76.48 μM.
Inhibited proliferation of HCT116 cells with an IC50 value of 17.94 μM.
Inhibited proliferation of MDA-MB-231 cells with an IC50 value of 8.01 μM.
Inhibited proliferation of PC3 cells with an IC50 value of >100 μM.
Inhibited proliferation of SK-hep-1 cells with an IC50 value of 28.89 μM.
Inhibited proliferation of SNU-638 cells with an IC50 value of 28.16 μM.
Chemical Information
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CAS No. 161128-65-0
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Molecular Weight 276.29
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Formula C13H16N4O3
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SMILES
NC1=NC=CC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)C(CCO)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chandra G, et al. Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities. Journal of medicinal chemistry. 2015 Jun 25;58(12):5108-20. [Content Brief]
[2]. Shuto S, et al. New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1. Journal of medicinal chemistry. 1996 Jun 07;39(12):2392-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Deazahomoneplanocin A Related Classifications
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