161128-65-0
161128-65-0
Chemical Structure
3-Deazahomoneplanocin A
- CAS 番号: 161128-65-0
- Formula:C13H16N4O3
- Molecular Weight:276.29
InChIKey: YTJUPDBQIRUHNR-JLLWLGSASA-N
SMILES: NC1=NC=CC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)C(CCO)=C3
Biological Activity: 3-Deazahomoneplanocin A is an S-adenosylhomocysteine (AdoHcy) hydrolase inhibitor with an IC50 of 3.76 μM. 3-Deazahomoneplanocin A exhibits antiviral activity against VSV. It also shows anticancer activity against lung cancer, colon cancer, breast cancer, liver cancer and gastric cancer[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
3-Deazahomoneplanocin A | 3-Deazahomoneplanocin A is an S-adenosylhomocysteine (AdoHcy) hydrolase inhibitor with an IC50 of 3.76 μM. 3-Deazahomoneplanocin A exhibits antiviral activity against VSV. It also shows anticancer activity against lung cancer, colon cancer, breast cancer, liver cancer and gastric cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chandra G, et al. Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities. Journal of medicinal chemistry. 2015 Jun 25;58(12):5108-20. [Content Brief]
- [2]. Shuto S, et al. New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1. Journal of medicinal chemistry. 1996 Jun 07;39(12):2392-9. [Content Brief]
