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Cat. No.: HY-W975617

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4',5,7,8-Tetrahydroxyflavanone

Name: 4',5,7,8-Tetrahydroxyflavanone
Brand: MedChemExpress
SKU: HY-W975617
Price: 540.00 USD
Availability: PreOrder

(Synonyms: Carthamidin)

4',5,7,8-Tetrahydroxyflavanone (Carthamidin) is a flavanone pigment. 4',5,7,8-Tetrahydroxyflavanone can be found in Carthamus tinctorius. 4',5,7,8-Tetrahydroxyflavanone induces ROS generation, oxidative stress, Apoptosis-mediated cell death, cell cycle arrest at G₀/G₁ phase, mitochondrial membrane potential collapse, and LDH leakage. 4',5,7,8-Tetrahydroxyflavanone exhibits anti-inflammatory, antioxidant, and neuroprotective effects, and acts as a reducing and capping agent for gold nanoparticles. 4',5,7,8-Tetrahydroxyflavanone can be used in breast cancer research.

For research use only. We do not sell to patients.

Purity : 96.25%
CAS No.: 479-54-9
Formula: C₁₅H₁₂O₆
Molecular Weight:288.25

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

4',5,7,8-Tetrahydroxyflavanone Chemical Structure

CAS No.: 479-54-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC50	128.65 μg/mL	Inhibition of proliferation of human breast cancer MCF 7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Inhibition of proliferation of human breast cancer MCF 7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	39704751

In Vitro

4',5,7,8-Tetrahydroxyflavanone (6.25-100 µg/mL; 24 h) effectively inhibits the proliferation of MCF 7 cells with an IC₅₀ of 128.65 µg/mL at 24 h^[1].
4',5,7,8-Tetrahydroxyflavanone (128 µg/mL) induces ROS in MCF 7 cells, thereby mediating the apoptosis process^[1].
4',5,7,8-Tetrahydroxyflavanone (128.65 µg/mL; 24 h) induces cell cycle arrest at the G0/G1 phase in MCF 7 cells, with 82.9% of cells residing there^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF 7
Concentration:

6.25-100 µg/mL
Incubation Time:

24 h
Result:

Inhibited the proliferation of MCF 7 cells in a dose-dependent manner.
The maximum inhibition was observed at 100 µg/mL.
The IC50 was determined as 128.65 µg/mL at 24 h.

Cell Cycle Analysis^[1]

Cell Line:

MCF 7
Concentration:

128.65 µg/mL
Incubation Time:

24 h
Result:

Increased the accumulation of DNA content to 82.9% in the G0/G1 phase.
Decreased DNA content in the S and G2/M phases to 6.5% and 10%, respectively, compared to the control (71.1% in G0/G1, 11.3% in S, and 15.2% in G2/M).

Chemical Information

CAS No. 479-54-9
Appearance Solid
Molecular Weight 288.25
Formula C₁₅H₁₂O₆
SMILES

O=C1C2=C(O)C(O)=C(O)C=C2O[C@H](C3=CC=C(C=C3)O)C1
Synonyms

Carthamidin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Palani S, et al. Apoptotic and Molecular Mechanisms of Carthamidin in Breast Cancer Therapy: An Integrated In Vitro and In Silico Study. Molecular biotechnology. 2025 Dec;67(12):4527-4541.

[2]. Joseph J, et al. Anti-proliferative activities of Carthamidin mediated gold nanoparticles against breast cancer: an in-vitro approach[J]. Nano-Structures & Nano-Objects, 2024, 39: 101324.

[3]. Özpeynirci A, et al. Safflower flower extracted carthamidin color pigment purification by adsorption chromatography and investigation of its use as a coloring agent in some foods[J]. Microchemical Journal, 2025: 116265.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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4',5,7,8-Tetrahydroxyflavanone