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5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

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5-HEPE

5-HEPE Estructura química

No. CAS : 92008-51-0

Tamaño Precio Stock Cantidad
Solvent
25 μg (314.02 μM * 250 μL in Ethanol) En stock
Solvent
50 μg (314.02 μM * 500 μL in Ethanol) Obtener un presupuesto
Solvent
100 μg (314.02 μM * 1 mL in Ethanol) Obtener un presupuesto

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Descripciòn

5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

IC50 & Target

Human Endogenous Metabolite

 

Peso molecular

318.45

Fòrmula

C20H30O3

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C=C\[C@@H](O)CCCC(O)=O

Initial Source
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Solution, -20°C, 2 years

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
5-HEPE
Cat. No.:
HY-113513
Cantidad:
MCE Japan Authorized Agent: