(±)15-HEPE
(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.
For research use only. We do not sell to patients.
- CAS No.: 88852-33-9
- Formula: C20H30O3
- Molecular Weight:318.45
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Storage:
Solution, -20°C, 2 years
Biological Activity
Chemical Information
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CAS No. 88852-33-9
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Appearance Liquid
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Molecular Weight 318.45
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Formula C20H30O3
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Color Colorless to light yellow
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SMILES
CC/C=C\CC(O)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
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Synonyms
(±)15-hydroxyeicosapentaenoic acid; 15-OHEPA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Desbois AP, Lawlor KC. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Mar Drugs. 2013;11(11):4544-4557. [Content Brief]
[2]. Lam BK, Hirai A, Yoshida S, Tamura Y, Wong PY. Transformation of 15-hydroperoxyeicosapentaenoic acid to lipoxin A5 and B5, mono- and dihydroxyeicosapentaenoic acids by porcine leukocytes. Biochim Biophys Acta. 1987;917(3):398-405. [Content Brief]
[3]. Lundström SL, Yang J, Källberg HJ, et al. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. PLoS One. 2012;7(3):e33780. [Content Brief]
[4]. Peh HY, Nshimiyimana R, Brüggemann TR, et al. 15-epi-lipoxin A5 promotes neutrophil exit from exudates for clearance by splenic macrophages. FASEB J. 2024;38(14):e23807. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)