88852-33-9
Chemical Structure
(±)15-HEPE
Synonym(s): (±)15-hydroxyeicosapentaenoic acid; 15-OHEPA
- CAS 番号: 88852-33-9
- Formula:C20H30O3
- Molecular Weight:318.45
IUPAC Name: (5Z,8Z,11Z,13E,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoic acid
InChIKey: WLKCSMCLEKGITB-XWJJKCKWSA-N
SMILES: CC/C=C\CC(O)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Biological Activity: (±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19.
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(±)15-HEPE | (±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE (HY-130675A). (±)15-HEPE is active against P. acnes and S. aureus (MICs = 128 and 512 mg/L, respectively). It inhibits aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP (IC50 = 4.7 µM). Bronchoalveolar lavage fluid (BALF) levels of (±)15-HEPE are increased in patients with allergic asthma or COVID-19. | |||||||||||||||||||||
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Keywords
