5'-O-DMT-2'-O-iBu-N-Bz-Guanosine (Synonyms: 5'-O-DMT-2'-O-TBDMS-ibu-rG)

Cat. No.: HY-43059 Purity: 99.07%: FAQs
Data Sheet SDS COA Handling Instructions

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5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides.

For research use only. We do not sell to patients.

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Chemical Structure

CAS No. : 81279-39-2

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250 mg	USD 27	In-stock	Estimated Time of Arrival: December 31
1 g	USD 67	In-stock	Estimated Time of Arrival: December 31
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Description

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides^[1].

Molecular Weight

769.96

Formula

C₄₁H₅₁N₅O₈Si

CAS No.

81279-39-2

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (129.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2988 mL	6.4938 mL	12.9877 mL
5 mM	0.2598 mL	1.2988 mL	2.5975 mL
10 mM	0.1299 mL	0.6494 mL	1.2988 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (3.25 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.25 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.07%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (255 KB) HNMR (293 KB) RP-HPLC (248 KB) MS (184 KB)

Handling Instructions (2659 KB)

References

[1]. Thomas P Blaisdell, et al. Practical silyl protection of ribonucleosides. Org Lett. 2013 Sep 20;15(18):4710-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2988 mL	6.4938 mL	12.9877 mL	32.4692 mL
	5 mM	0.2598 mL	1.2988 mL	2.5975 mL	6.4938 mL
	10 mM	0.1299 mL	0.6494 mL	1.2988 mL	3.2469 mL
	15 mM	0.0866 mL	0.4329 mL	0.8658 mL	2.1646 mL
	20 mM	0.0649 mL	0.3247 mL	0.6494 mL	1.6235 mL
	25 mM	0.0520 mL	0.2598 mL	0.5195 mL	1.2988 mL
	30 mM	0.0433 mL	0.2165 mL	0.4329 mL	1.0823 mL
	40 mM	0.0325 mL	0.1623 mL	0.3247 mL	0.8117 mL
	50 mM	0.0260 mL	0.1299 mL	0.2598 mL	0.6494 mL
	60 mM	0.0216 mL	0.1082 mL	0.2165 mL	0.5412 mL
	80 mM	0.0162 mL	0.0812 mL	0.1623 mL	0.4059 mL
	100 mM	0.0130 mL	0.0649 mL	0.1299 mL	0.3247 mL

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine81279-39-25'-O-DMT-2'-O-TBDMS-ibu-rGNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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