5’-O-Triphenylmethyl-2’-deoxyuridine
5’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 14270-73-6
- Formula: C28H26N2O5
- Molecular Weight:470.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| L6 | EC50 |
192 μM
Compound: Fig1, R1C1
|
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
|
[PMID: 21411327] |
| L6 | IC50 |
192 μM
Compound: 1j
|
In vitro cytotoxicity aganist rat skeletal myoblasts (L-6 cells) after 72 hours
In vitro cytotoxicity aganist rat skeletal myoblasts (L-6 cells) after 72 hours
|
[PMID: 16161998] |
| L6 | IC50 |
192 μM
Compound: 1a
|
Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
|
[PMID: 16821778] |
| Vero | CC50 |
5 μM
Compound: 2b
|
Cytotoxicity against african green monkey Vero cells after 1 week
Cytotoxicity against african green monkey Vero cells after 1 week
|
[PMID: 23721953] |
| Vero | EC50 |
3 μM
Compound: 2b
|
Antiviral activity against YFV 17D infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 1 week
Antiviral activity against YFV 17D infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 1 week
|
[PMID: 23721953] |
Chemical Information
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CAS No. 14270-73-6
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Molecular Weight 470.52
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Formula C28H26N2O5
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SMILES
O=C(C=CN1[C@H]2C[C@H](O)[C@@H](COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O2)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)