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Cat. No.: HY-101532

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6A-Azido-6A-deoxy-β-cyclodextrin

(Synonyms: β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin)

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6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 98169-85-8
Formula: C₄₂H₆₉N₃O₃₄
Molecular Weight:1160.00

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

6A-Azido-6A-deoxy-β-cyclodextrin Chemical Structure

CAS No.: 98169-85-8

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

6A-Azido-6A-deoxy-β-cyclodextrin is isolated as a stable intermediate following nucleophilic substitution of 6A-monotosyl-β-cyclodextrin with sodium azide at 80 °C in DMF^[1].
6A-Azido-6A-deoxy-β-cyclodextrin (0.54-1.6 µmol; overnight, room temperature) conjugates to dPG-BCN via SPAAC at room temperature to form dPG-βCD conjugates with 1% and 3% βCD functionalization, which exhibit reduced water solubility with higher βCD content^[2].
6A-Azido-6A-deoxy-β-cyclodextrin (34 µmol; 1 h, 45 °C) successfully grafts to the surface of thermoresponsive nanogels via SPAAC post-functionalization, forming stable spherical particles with minor reduction in thermoresponsive cloud point temperature and confirmed βCD presence via ANS fluorescence^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 98169-85-8
Appearance Solid
Molecular Weight 1160.00
Formula C₄₂H₆₉N₃O₃₄
Color White to off-white
SMILES

[N-]=[N+]=NC[C@@H](O[C@@](O[C@]([C@@H]1O)([H])[C@H](O[C@@](O[C@]([C@@H]2O)([H])[C@H](O[C@@](O[C@]([C@@H]([C@H]3O)O)([H])[C@H]4CO)([H])[C@@H]2O)CO)([H])[C@@H]1O)CO)([H])[C@H](O)[C@H]5O)[C@@]5([H])O[C@@]([C@@H]([C@@H](O)[C@]6([H])O[C@@]([C@@H]([C@@H](O)[C@]7([H])O[C@@]([C@@H]([C@@H](O)[C@]8([H])O[C@@]3([H])O4)O)([H])O[C@@H]8CO)O)([H])O[C@@H]7CO)O)([H])O[C@@H]6CO
Synonyms

β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (107.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8621 mL

4.3103 mL

8.6207 mL

5 mM

0.1724 mL

0.8621 mL

1.7241 mL

10 mM

0.0862 mL

0.4310 mL

0.8621 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dauchy M, et al. New water-soluble Schiff base ligands based on β-cyclodextrin for aqueous biphasic hydroformylation reaction[J]. Pure and Applied Chemistry, 2018, 90(5): 845-855.

[2]. Giulbudagian M, et al. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels. Nanoscale. 2017 Dec 21;10(1):469-479. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8621 mL	4.3103 mL	8.6207 mL	21.5517 mL
	5 mM	0.1724 mL	0.8621 mL	1.7241 mL	4.3103 mL
	10 mM	0.0862 mL	0.4310 mL	0.8621 mL	2.1552 mL
	15 mM	0.0575 mL	0.2874 mL	0.5747 mL	1.4368 mL
	20 mM	0.0431 mL	0.2155 mL	0.4310 mL	1.0776 mL
	25 mM	0.0345 mL	0.1724 mL	0.3448 mL	0.8621 mL
	30 mM	0.0287 mL	0.1437 mL	0.2874 mL	0.7184 mL
	40 mM	0.0216 mL	0.1078 mL	0.2155 mL	0.5388 mL
	50 mM	0.0172 mL	0.0862 mL	0.1724 mL	0.4310 mL
	60 mM	0.0144 mL	0.0718 mL	0.1437 mL	0.3592 mL
	80 mM	0.0108 mL	0.0539 mL	0.1078 mL	0.2694 mL
	100 mM	0.0086 mL	0.0431 mL	0.0862 mL	0.2155 mL

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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6A-Azido-6A-deoxy-β-cyclodextrin

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

6A-Azido-6A-deoxy-β-cyclodextrin Related Classifications

HY-101532 Related Classifications